产品名称

英文名称：Foropafant

同义词

piperidine-1,4-dicarboxylic acid tert-butyl ester ethyl ester 、 N-(2-Dimethylaminoethyl)-N-(3-pyridinylmethyl)(4-(2,4,6-triisopropylphenyl)thiazol-2-yl)amine 、 N,N-Dimethyl-N'-(3-pyridinylmethyl)-N'-(4-(2,4,6-tris(1-methylethyl)phenyl)-2-thiazolyl)-1,2-et、N1,N1-二甲基-N2-(吡啶-3-基甲基)-N2-(4-(2,4,6-三异丙基苯基)噻唑-2-基)乙烷-1,2-二胺

产品性质

CAS编号：136468-36-5

分子式：C28H40N4S

分子量：464.71

PubChem编号：119368

别名：N1,N1-二甲基-N2-(吡啶-3-基甲基)-N2-(4-(2,4,6-三异丙基苯基)噻唑-2-基)乙烷-1,2-二胺

英文别名：piperidine-1,4-dicarboxylic acid tert-butyl ester ethyl ester | N-(2-Dimethylaminoethyl)-N-(3-pyridinylmethyl)(4-(2,4,6-triisopropylphenyl)thiazol-2-yl)amine | N,N-Dimethyl-N'-(3-pyridinylmethyl)-N'-(4-(2,4,6-tris(1-methylethyl)phenyl)-2-thiazolyl)-1,2-et

规格或纯度：≥98% (HPLC)

英文名称：Foropafant

生化机理：SR 27417 is a long-acting, highly potent, specific competitive platelet-activating factor (PAF) receptor antagonist.

储存温度：2-8°C储存

运输条件：冰袋运输

产品介绍：Foropafant (SR27417) 是一种高效、竞争性、选择性、可口服的血小板激活因子 (PAF) 受体拮抗剂，抑制 [3H]PAF 与其受体结合，Ki 值为 57 pM，比未被标记的 PAF 低至少 5 倍。Foropafant (SR27417) 有效抑制 PAF 诱导的兔和人血小板聚集Foropafant (SR27417) is a highly potent, competitive, selective, and orally available platelet activator (PAF) receptor antagonist that inhibits [3H]PAF from binding to its receptor with a Ki of 57 pM, at least five times lower than unlabeled PAF. Foropafant (SR27417) effectively inhibits PAF-induced platelet aggregation in rabbits and humans

IUPAC Name：N,N-dimethyl-N'-(pyridin-3-ylmethyl)-N'-[4-[2,4,6-tri(propan-2-yl)phenyl]-1,3-thiazol-2-yl]ethane-1,2-diamine

INCHI：InChI=1S/C28H40N4S/c1-19(2)23-14-24(20(3)4)27(25(15-23)21(5)6)26-18-33-28(30-26)32(13-12-31(7)8)17-22-10-9-11-29-16-22/h9-11,14-16,18-21H,12-13,17H2,1-8H3

InChi Key：VVBFISAUNSXQGZ-UHFFFAOYSA-N

Canonical SMILES：CC(C)C1=CC(=C(C(=C1)C(C)C)C2=CSC(=N2)N(CCN(C)C)CC3=CN=CC=C3)C(C)C

Isomeric SMILES：CC(C)C1=CC(=C(C(=C1)C(C)C)C2=CSC(=N2)N(CCN(C)C)CC3=CN=CC=C3)C(C)C

WGK Germany：3

PubChem CID：119368

CAS Registry No.：136468-36-5

ChEMBL Ligand：CHEMBL1628662

RCSB PDB Ligand：9ER

GPCRdb Ligand：foropafant

溶解性：DMSO 5 mg/mL (clear solution, warmed)

象形图：

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

产品包装