产品名称

英文名称：3CAI

同义词

2-Chloro-1-(1H-indol-3-yl)ethanone 、 3-Chloroacetyl-indole 、 Chloromethyl indol-3-yl ketone、2-氯-1-(1H-吲哚-3-基)乙酮

产品性质

CAS编号：28755-03-5

分子式：C10H8ClNO

分子量：193.63

PubChem编号：152961

别名：2-氯-1-(1H-吲哚-3-基)乙酮

英文别名：2-Chloro-1-(1H-indol-3-yl)ethanone | 3-Chloroacetyl-indole | Chloromethyl indol-3-yl ketone

规格或纯度：95% (HPLC)

英文名称：3CAI

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：产品介绍3CAI 是一种有效的特异性 AKT1 和 AKT2 抑制剂。product describtionA cell-permeable chloroacetyl-indole compound that inhibits Akt1 and Akt2 kinase activity (IC50<1 µM) by directly targeting Akt PH domain, exhibiting little or much reduced activity against a panel of 84 other kinases, including PI-3 Kinase (60% inhibition at 10 µM). Effectively inhibits Akt-mediated cellular GSK3β Ser9 and mTOR Ser2448 phosphorylation (4 µM in HCT116 cultures) in a time-dependent manner, resulting in effective apoptosis induction in HCT116 and HT29 cultures (by 55% and 60%, respectively; 4 µM for 4 days). Reported to retard HCT116-derived tumor growth by 50% when administered at an oral dosage of 30 mg/kg in mice (5 times/wk for 3 wks) in vivo.

IUPAC Name：2-chloro-1-(1H-indol-3-yl)ethanone

INCHI：InChI=1S/C10H8ClNO/c11-5-10(13)8-6-12-9-4-2-1-3-7(8)9/h1-4,6,12H,5H2

InChi Key：LLZQFAXTCYDVTR-UHFFFAOYSA-N

Canonical SMILES：C1=CC=C2C(=C1)C(=CN2)C(=O)CCl

Isomeric SMILES：C1=CC=C2C(=C1)C(=CN2)C(=O)CCl

WGK Germany：3

PubChem CID：152961

溶解性：DMSO 100 mg/mL

敏感性：对光线敏感

象形图：

信号词：Warning

危险声明：H319 Causes serious eye irritationH302 Harmful if swallowed

预防措施声明：P305+P351+P338,P280,P501,P264,P270,P330,P264+P265,P301+P317,P337+P317

产品包装