产品名称

英文名称：Narciclasine

同义词

Lycoricidin-A 、 MFCD01729949 、 [1,3]Dioxolo[4,5-j]phenanthridin-6(2H)-one, 3,4,4a,5-tetrahydro-2,3,4,7-tetrahydroxy-, (2S,3R,4S,4aR) 、 [1,3]Dioxolo[4,5-j]phenanthridin-6(2H)-one, 3,4,4a,5-tetrahydro-2,3,4,7-tetrahydroxy-, (2S,3R,4S,4aR)- 、 3,4,4a,5-Tetrah

产品性质

CAS编号：29477-83-6

分子式：C14H13NO7

分子量：307.26

MDL号：MFCD01729949

PubChem编号：72376

英文别名：Lycoricidin-A | MFCD01729949 | [1,3]Dioxolo[4,5-j]phenanthridin-6(2H)-one, 3,4,4a,5-tetrahydro-2,3,4,7-tetrahydroxy-, (2S,3R,4S,4aR) | [1,3]Dioxolo[4,5-j]phenanthridin-6(2H)-one, 3,4,4a,5-tetrahydro-2,3,4,7-tetrahydroxy-, (2S,3R,4S,4aR)- | 3,4,4a,5-Tetrah

规格或纯度：≥98%

英文名称：Narciclasine

生化机理：Narciclasine modulates the Rho/ROCK/LIM kinase/cofilin pathway; stimulates RhoA activation and induces actin polymerization. The cytostatic activity of Narciclasine involves the impairment of actin cytoskeleton organization by targeting GTPases, including RhoA and the elongation factor eEF1A. Thus, Narciclasine is a potentially promising agent for the treatment of primary brain cancers and various brain metastases. Also Narciclasine is an actin stress fiber formation inducer; a plant growth modulator.Plant growth\xa0regulator originally\xa0isolated from Narcissus bulbs. Exhibits antiproliferative and pro-apoptotic effects in carcinoma cells and displays cytotoxic activity against a panel of 60 cancer cell lines (mean IC 50 = 47 nM). Activity decreases

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Narciclasine是一种植物生长调节剂。 Narciclasine调节Rho/Rho 激酶/LIM 激酶/cofilin信号传导途径，大大增加GTP酶RhoA活性以及以RhoA依赖性方式诱导肌动蛋白应力纤维形成。Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.

IUPAC Name：(2S,3R,4S,4aR)-2,3,4,7-tetrahydroxy-3,4,4a,5-tetrahydro-2H-[1,3]dioxolo[4,5-j]phenanthridin-6-one

INCHI：InChI=1S/C14H13NO7/c16-6-1-5-4-2-7-13(22-3-21-7)11(18)8(4)14(20)15-9(5)12(19)10(6)17/h1-2,6,9-10,12,16-19H,3H2,(H,15,20)/t6-,9+,10+,12-/m0/s1

InChi Key：LZAZURSABQIKGB-AEKGRLRDSA-N

Canonical SMILES：C1OC2=C(O1)C(=C3C(=C2)C4=CC(C(C(C4NC3=O)O)O)O)O

Isomeric SMILES：C1OC2=C(O1)C(=C3C(=C2)C4=C[C@@H]([C@H]([C@H]([C@@H]4NC3=O)O)O)O)O

PubChem CID：72376

溶解性：DMSO

象形图：

信号词：Danger

危险声明：H340 May cause genetic defects

预防措施声明：P405,P501,P281,P203,P318

产品包装