产品名称

英文名称：PD0325901

同义词

391210-10-9、PD0325901、PD 0325901、Mirdametinib、PD-0325901、(R)-N-(2,3-Dihydroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide、PD-325901、(R)-N-(2,3-DIHYDROXYPROPOXY)-3,4-DIFLUORO-2-(2-FLUORO-4-IODOPHENYLAMINO)BENZAMIDE、N-[(2R)-2,3-dihydroxyp

产品性质

CAS编号：391210-10-9

分子式：C16H14F3IN2O4

分子量：482.19

PubChem编号：9826528

英文别名：391210-10-9|PD0325901|PD 0325901|Mirdametinib|PD-0325901|(R)-N-(2,3-Dihydroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide|PD-325901|(R)-N-(2,3-DIHYDROXYPROPOXY)-3,4-DIFLUORO-2-(2-FLUORO-4-IODOPHENYLAMINO)BENZAMIDE|N-[(2R)-2,3-dihydroxyp

规格或纯度：≥99%

英文名称：PD0325901

生化机理：强大的MEK1和MEK2抑制剂。抑制小鼠结肠26细胞中的MEK活性（IC50 = 0.33 nM）。体内和体外抑制黑素瘤细胞系的生长；在小鼠异种移植模型中诱导G1期细胞周期停滞和凋亡。还抑制促血管生成细胞因子（例如VEGF）的产生。增强诱导性多能干细胞（iPSC）的生成。口服有效。

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：25mg、100mg卖完停产，不再备货

产品介绍：PD0325901是一种选择性的，ATP非竞争性的MEK抑制剂，IC50为0.33 nM，对ERK1和ERK2磷酸化抑制作用比CI-1040强500倍左右An inhibitor of MEK and suppressor of ERK phosphorylationPD0325901 (PD325901) is selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM, roughly 500-fold more potent than CI-1040 on phosphorylation of ERK1 and ERK2.An inhibitor of MEK and suppressor of ERK phosphorylation

IUPAC Name：N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide

INCHI：InChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1

InChi Key：SUDAHWBOROXANE-SECBINFHSA-N

Canonical SMILES：C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOCC(CO)O

Isomeric SMILES：C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOC[C@@H](CO)O

WGK Germany：3

PubChem CID：9826528

ChEMBL Ligand：CHEMBL507361

CAS Registry No.：391210-10-9

RCSB PDB Ligand：4BM

Reactome Reaction：R-HSA-9657606

Reactome Drug：R-ALL-9657553

溶解性：溶于DMSO, 最高浓度 (mg/mL) 12.05, 最高浓度(mM) 25

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowedH373 Causes damage to organs through prolonged or repeated exposureH400 Very toxic to aquatic lifeH410 Very toxic to aquatic life with long lasting effects

预防措施声明：P273,P321,P405,P501,P264,P260,P270,P391,P330,P301+P316,P319

产品包装