产品名称

英文名称：BX-795

同义词

702675-74-9、BX795、BX-795、BX 795、N-[3-[[5-IODO-4-[[3-[(2-THIENYLCARBONYL)AMINO]PROPYL]AMINO]-2-PYRIMIDINYL]AMINO]PHENYL]-1-PYRROLIDINECARBOXAMIDE、N-(3-((5-iodo-4-((3-(thiophene-2-carboxamido)propyl)amino)pyrimidin-2-yl)amino)phenyl)pyrrolidine-1-carboxamid

产品性质

CAS编号：702675-74-9

分子式：C23H26IN7O2S

分子量：591.47

PubChem编号：10077147

英文别名：702675-74-9|BX795|BX-795|BX 795|N-[3-[[5-IODO-4-[[3-[(2-THIENYLCARBONYL)AMINO]PROPYL]AMINO]-2-PYRIMIDINYL]AMINO]PHENYL]-1-PYRROLIDINECARBOXAMIDE|N-(3-((5-iodo-4-((3-(thiophene-2-carboxamido)propyl)amino)pyrimidin-2-yl)amino)phenyl)pyrrolidine-1-carboxamid

规格或纯度：≥97%

英文名称：BX-795

生化机理：BX 795 is shown to be a specific and potent inhibitor of IκB kinase ε (IKKε), phosphoinositide 3-kinase 1 (PDK1), and TANK-binding kinase 1 (TBK1). These protein kinases regulate production of type 1 interferons during certain infections. BX 795 has been sμggested in studies to block nuclear translocation, phosphorylation, and transcriptional activity of interferon regulatory factor 3. This in turn blocks the production of interferon-β in macrophages. Further experiments have shown that BX 795 is capable of blocking the autophosphorylation of overexpressed TBK1 and IκKε.PDK1 inhibitor. Potent TBK1 and IKKε inhibitor. Blocks PDK1/Akt signaling. Inhibits anchorage-dependent growth of tumor cells. Blocks phosphorylation, nuclear translocation, and transcriptional activity of interferon regulatory factor 3.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：BX-795是一种有效的，特异性的PDK1抑制剂，IC50为6 nM，作用于PDK1比作用于PKA和PKC选择性分别高140和1600倍。An inhibitor of PDK1, TBK1, and IKK&epsilonBX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.An inhibitor of PDK1, TBK1, and IKK&epsilon

IUPAC Name：N-[3-[[5-iodo-4-[3-(thiophene-2-carbonylamino)propylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide

INCHI：InChI=1S/C23H26IN7O2S/c24-18-15-27-22(30-20(18)25-9-5-10-26-21(32)19-8-4-13-34-19)28-16-6-3-7-17(14-16)29-23(33)31-11-1-2-12-31/h3-4,6-8,13-15H,1-2,5,9-12H2,(H,26,32)(H,29,33)(H2,25,27,28,30)

InChi Key：VAVXGGRQQJZYBL-UHFFFAOYSA-N

Canonical SMILES：C1CCN(C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)NCCCNC(=O)C4=CC=CS4)I

Isomeric SMILES：C1CCN(C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)NCCCNC(=O)C4=CC=CS4)I

PubChem CID：10077147

ChEMBL Ligand：CHEMBL577784

CAS Registry No.：702675-74-9

RCSB PDB Ligand：BX7

溶解性：DMSO 100 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

产品包装