产品名称

英文名称：GSK256066

同义词

GSK256066、801312-28-7、GSK-256066、6-[[3-[(DIMETHYLAMINO)CARBONYL]PHENYL]SULFONYL]-4-[(3-METHOXYPHENYL)AMINO]-8-METHYL-3-QUINOLINECARBOXAMIDE、6-(3-(dimethylcarbamoyl)phenylsulfonyl)-4-(3-methoxyphenylamino)-8-methylquinoline-3-carboxamide、GSK 256066、6-[3-(D

产品性质

CAS编号：801312-28-7

分子式：C27H26N4O5S

分子量：518.58

PubChem编号：9827968

英文别名：GSK256066|801312-28-7|GSK-256066|6-[[3-[(DIMETHYLAMINO)CARBONYL]PHENYL]SULFONYL]-4-[(3-METHOXYPHENYL)AMINO]-8-METHYL-3-QUINOLINECARBOXAMIDE|6-(3-(dimethylcarbamoyl)phenylsulfonyl)-4-(3-methoxyphenylamino)-8-methylquinoline-3-carboxamide|GSK 256066|6-[3-(D

规格或纯度：≥98%

英文名称：GSK256066

生化机理：GSK256066 is a slow and tight binding inhibitor of PDE4B with apparent IC50 of 3.2 pM. GSK256066 is an extremely potent inhibitor of LPS-stimulated TNFα production in PBMCs with pIC50 of 11.0 and IC50 of 10 pM and human whole-blood cultures with pIC50 of 9.90 and IC50 of 126 pM. GSK256066 is highly selective for PDE4 (>3.8 × 105-fold versus PDE1, PDE2, PDE3, PDE5, and PDE6 and >2.5 × 103-fold against PDE7). GSK256066 inhibits PDE4 isoforms A-D with equal affinity.

应用：A highly potent and selective inhibitor of phosphodiesterase 4

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：GSK256066是PDE4B抑制剂，IC50为3.2 pM，与A-D各亚型亲和力相同，比对PDE1/2/3/5/6和PDE7的抑制性高380000倍和2500倍。A highly potent and selective inhibitor of phosphodiesterase 4GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7A highly potent and selective inhibitor of phosphodiesterase 4

IUPAC Name：6-[3-(dimethylcarbamoyl)phenyl]sulfonyl-4-(3-methoxyanilino)-8-methylquinoline-3-carboxamide

INCHI：InChI=1S/C27H26N4O5S/c1-16-11-21(37(34,35)20-10-5-7-17(12-20)27(33)31(2)3)14-22-24(16)29-15-23(26(28)32)25(22)30-18-8-6-9-19(13-18)36-4/h5-15H,1-4H3,(H2,28,32)(H,29,30)

InChi Key：JFHROPTYMMSOLG-UHFFFAOYSA-N

Canonical SMILES：CC1=CC(=CC2=C(C(=CN=C12)C(=O)N)NC3=CC(=CC=C3)OC)S(=O)(=O)C4=CC=CC(=C4)C(=O)N(C)C

Isomeric SMILES：CC1=CC(=CC2=C(C(=CN=C12)C(=O)N)NC3=CC(=CC=C3)OC)S(=O)(=O)C4=CC=CC(=C4)C(=O)N(C)C

PubChem CID：9827968

溶解性：DMSO 5 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

象形图：

信号词：Danger

危险声明：H335 May cause respiratory irritationH373 Causes damage to organs through prolonged or repeated exposureH330 Fatal if inhaled

预防措施声明：P261,P405,P501,P260,P284,P271,P304+P340,P403+P233,P320,P316,P319

产品包装