产品名称

英文名称：LX-1031

同义词

LX-1031、945976-76-1、LX1031、J08E1J78GK、L-Phenylalanine, 4-(2-amino-6-((1R)-2,2,2-trifluoro-1-(3'-methoxy(1,1'-biphenyl)-4-yl)ethoxy)-4-pyrimidinyl)-、LX 1031、(S)-2-Amino-3-(4-(2-amino-6-((R)-2,2,2-trifluoro-1-(3'-methoxy-[1,1'-biphenyl]-4-yl)ethoxy)pyrimidi

产品性质

CAS编号：945976-76-1

分子式：C28H25F3N4O4

分子量：538.52

PubChem编号：23633604

英文别名：LX-1031|945976-76-1|LX1031|J08E1J78GK|L-Phenylalanine, 4-(2-amino-6-((1R)-2,2,2-trifluoro-1-(3'-methoxy(1,1'-biphenyl)-4-yl)ethoxy)-4-pyrimidinyl)-|LX 1031|(S)-2-Amino-3-(4-(2-amino-6-((R)-2,2,2-trifluoro-1-(3'-methoxy-[1,1'-biphenyl]-4-yl)ethoxy)pyrimidi

规格或纯度：≥98%

英文名称：LX-1031

生化机理：LX-1031 is an oral, small molecule tryptophan 5-hydroxylase (TPH) inhibitor that reduces serotonin (5-HT) synthesis peripherally. LX1031 has potential for illnesses characterized by excess 5-HT, such as diarrhea-predominant irritable bowel syndrome (IBS-D) and carcinoid diarrhea.Small molecule inhibitor of tryptophan 5-hydroxylase (TPH).\xa0A heterocyclic substituted phenylalanine analog. Inhibits TPH1\xa0 in vitro in the concentration range 10 -7 - 10 -8 M. Reduces synthesis of serotonin (5-HT) peripherally and is being develope

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：LX-1031 是一种有效的色氨酸5-羟化酶抑制剂，能够减少5-羟色胺的合成。LX-1031 is a potent tryptophan 5-hydroxylase (TPH) inhibitor that reduces serotonin (5-HT) synthesis peripherally.

IUPAC Name：(2S)-2-amino-3-[4-[2-amino-6-[(1R)-2,2,2-trifluoro-1-[4-(3-methoxyphenyl)phenyl]ethoxy]pyrimidin-4-yl]phenyl]propanoic acid

INCHI：InChI=1S/C28H25F3N4O4/c1-38-21-4-2-3-20(14-21)17-9-11-19(12-10-17)25(28(29,30)31)39-24-15-23(34-27(33)35-24)18-7-5-16(6-8-18)13-22(32)26(36)37/h2-12,14-15,22,25H,13,32H2,1H3,(H,36,37)(H2,33,34,35)/t22-,25+/m0/s1

InChi Key：XNMUICFMGGQSMZ-WIOPSUGQSA-N

Canonical SMILES：COC1=CC=CC(=C1)C2=CC=C(C=C2)C(C(F)(F)F)OC3=NC(=NC(=C3)C4=CC=C(C=C4)CC(C(=O)O)N)N

Isomeric SMILES：COC1=CC=CC(=C1)C2=CC=C(C=C2)[C@H](C(F)(F)F)OC3=NC(=NC(=C3)C4=CC=C(C=C4)C[C@@H](C(=O)O)N)N

PubChem CID：23633604

溶解性：DMSO

产品包装