产品名称

英文名称：AMG-208

同义词

AMG-208、1002304-34-8、AMG208、AMG 208、7-methoxy-4-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy)quinoline、UNII-Y2SR66P7VM、Y2SR66P7VM、CHEBI90626、7-methoxy-4-[(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline、7-methoxy-4-[(6-phenyl[1

产品性质

CAS编号：1002304-34-8

分子式：C22H17N5O2

分子量：383.41

PubChem编号：24864821

英文别名：AMG-208|1002304-34-8|AMG208|AMG 208|7-methoxy-4-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy)quinoline|UNII-Y2SR66P7VM|Y2SR66P7VM|CHEBI90626|7-methoxy-4-[(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline|7-methoxy-4-[(6-phenyl[1

规格或纯度：≥98%

英文名称：AMG-208

生化机理：AMG-208 shows the potent inhibition of kinase c-Met activity with IC50 of 9 nM in a cell-free assay. Besides, AMG-208 treatment also leads to the inhibition of HGF-mediated c-Met phosphorylation in PC3 cells with IC50 of 46 nM . Pre-incubation of AMG-208 with human liver microsomes for 30 minutes shows a potent time-dependent inhibition for CYP3A4 metabolic activity with IC50 of 4.1 μM, which is an eightfold decrease relative to the IC50 (32 μM) without preincubation . AMG-208 is identified to be a c-MET and RON dual selective inhibitor

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：AMG-208是c-Met抑制剂，IC50为9.3 nM。A highly selective Met inhibitor (IC50 = 9.3 nM)AMG-208 is a potent small molecular c-Met inhibitor with an IC50 of 9.3 nM.A highly selective Met inhibitor (IC50 = 9.3 nM)

ALogP：3.1

IUPAC Name：7-methoxy-4-[(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline

INCHI：InChI=1S/C22H17N5O2/c1-28-16-7-8-17-19(13-16)23-12-11-20(17)29-14-22-25-24-21-10-9-18(26-27(21)22)15-5-3-2-4-6-15/h2-13H,14H2,1H3

InChi Key：HEAIZQNMNCHNFD-UHFFFAOYSA-N

Canonical SMILES：COC1=CC2=NC=CC(=C2C=C1)OCC3=NN=C4N3N=C(C=C4)C5=CC=CC=C5

Isomeric SMILES：COC1=CC2=NC=CC(=C2C=C1)OCC3=NN=C4N3N=C(C=C4)C5=CC=CC=C5

PubChem CID：24864821

溶解性：DMSO 0.25 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

产品包装