产品名称

英文名称：MK-2048

同义词

MK-2048、869901-69-9、MK2048、(6s)-2-(3-Chloro-4-Fluorobenzyl)-8-Ethyl-10-Hydroxy-N,6-Dimethyl-1,9-Dioxo-1,2,6,7,8,9-Hexahydropyrazino[1',2'1,5]pyrrolo[2,3-D]pyridazine-4-Carboxamide、MK 2048、LJ8U884TM5、(S)-2-(3-Chloro-4-fluorobenzyl)-8-ethyl-10-hydroxy-N,6-

产品性质

CAS编号：869901-69-9

分子式：C21H21ClFN5O4

分子量：461.87

PubChem编号：54698642

英文别名：MK-2048|869901-69-9|MK2048|(6s)-2-(3-Chloro-4-Fluorobenzyl)-8-Ethyl-10-Hydroxy-N,6-Dimethyl-1,9-Dioxo-1,2,6,7,8,9-Hexahydropyrazino[1',2'1,5]pyrrolo[2,3-D]pyridazine-4-Carboxamide|MK 2048|LJ8U884TM5|(S)-2-(3-Chloro-4-fluorobenzyl)-8-ethyl-10-hydroxy-N,6-

规格或纯度：≥98%

英文名称：MK-2048

生化机理：MK-2048 is a second generation integrase inhibitor, intended to be used against HIV infection. MK-2048 inhibits subtype B and subtype C integrase activities. MK-2048 inhibits R263K mutants slightly more effectively than G118R mutants. MK-2048 inhibits S217H intasome and, by contrast, MK-2048 remains fully active against the N224H intasome. MK-2048 displays substantially lower dissociation rates compared with raltegravir, another integrase inhibitor. MK-2048 is active against viruses resistant to RAL and EVG. MK-2048 exposure leads to the selection of G118R as a possible novel resistance mutation after 19 weeks. MK-2048, with continued pressure, subsequently leads to an additional substitution, at position E138K, after 29 weeks, within the IN gene. Althoμgh the G118R mutation alone confers only slight resistance to MK-2048 but not to RAL or EVG, its presence arouses a dramatic reduction in viral replication capacity compared to wild-type NL4-3. E138K both partially restores viral replication capacity and also contributes to increased levels of resistance against MK-2048.MK-2048 is a potent inhibitor of integrase (IN) and IN R263K with IC 50 of 2.6nM and 1.5nM respectively.

储存温度：-20°C储存

运输条件：超低温冰袋运输

IUPAC Name：(13S)-5-[(3-chloro-4-fluorophenyl)methyl]-11-ethyl-8-hydroxy-N,13-dimethyl-6,10-dioxo-1,4,5,11-tetrazatricyclo[7.4.0.02,7]trideca-2(7),3,8-triene-3-carboxamide

INCHI：InChI=1S/C21H21ClFN5O4/c1-4-26-8-10(2)28-16-14(18(29)17(28)21(26)32)20(31)27(25-15(16)19(30)24-3)9-11-5-6-13(23)12(22)7-11/h5-7,10,29H,4,8-9H2,1-3H3,(H,24,30)/t10-/m0/s1

InChi Key：JSRREMIKIHJGAA-JTQLQIEISA-N

Canonical SMILES：CCN1CC(N2C3=C(C(=C2C1=O)O)C(=O)N(N=C3C(=O)NC)CC4=CC(=C(C=C4)F)Cl)C

Isomeric SMILES：CCN1C[C@@H](N2C3=C(C(=C2C1=O)O)C(=O)N(N=C3C(=O)NC)CC4=CC(=C(C=C4)F)Cl)C

PubChem CID：54698642

溶解性：DMSO 9 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

产品包装