EVP-6124,nAChRs激动剂

产品分类

研究领域/神经科学/神经学过程/神经信号转导

产品名称

中文名称：EVP-6124,nAChRs激动剂

英文名称：EVP-6124

同义词

Encenicline、EVP-6124、550999-75-2、EVP 6124、UNII-5FI5376A0X、EVP6124、Encenicline [USANINN]、5FI5376A0X、FRM-6124、(r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide、N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-7-chloro-1-benzothiophene-2-carboxamide、CH

产品性质

CAS编号：550999-75-2

分子式：C16H17ClN2OS

分子量：320.84

PubChem编号：46196517

英文名称：EVP-6124

生化机理：EVP-6124, its alpha-7 nicotinic acetylcholine receptor agonist, possesses a novel mechanism not previously seen in the scientific community it acts as a co-agonist with Acetylcholine (ACh) to enhance cognition. By acting as a co-agonist and sensitizing the alpha-7 receptor, EVP-6124 makes it possible for smaller amounts of naturally occurring ACh, typically found in individuals with memory disorders such as Alzheimer's, to be required to activate the receptor. In this scenario, research demonstrated that memory deficits can be minimized or entirely reversed by controlling the neuronal channel with EVP-6124 alone or in combination with other Alzheimer's drμgs.

储存温度：-20°C储存

运输条件：超低温冰袋运输

ALogP：3.8

IUPAC Name：N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-7-chloro-1-benzothiophene-2-carboxamide

INCHI：InChI=1S/C16H17ClN2OS/c17-12-3-1-2-11-8-14(21-15(11)12)16(20)18-13-9-19-6-4-10(13)5-7-19/h1-3,8,10,13H,4-7,9H2,(H,18,20)/t13-/m0/s1

InChi Key：SSRDSYXGYPJKRR-ZDUSSCGKSA-N

Canonical SMILES：C1CN2CCC1C(C2)NC(=O)C3=CC4=C(S3)C(=CC=C4)Cl

PubChem CID：46196517

ChEMBL Ligand：CHEMBL2151572

CAS Registry No.：550999-75-2

Wikipedia：Encenicline

RCSB PDB Ligand：I33

溶解性：DMSO

产品包装