产品名称

英文名称：LY2795050

同义词

LY2795050、1346133-08-1、LY-2795050、71PAL357HO、CHEMBL1921842、Benzamide, 3-chloro-4-(4-(((2S)-2-(3-pyridinyl)-1-pyrrolidinyl)methyl)phenoxy)-benzamide, 3-chloro-4-(4-(((2S)-2-(3-pyridinyl)-1-pyrrolidinyl)methyl)phenoxy)-、3-Chloro-4-[4-[[(2S)-2-pyridin-3-ylpy

产品性质

CAS编号：1346133-08-1

分子式：C23H22ClN3O2

分子量：407.89

PubChem编号：56851583

英文别名：LY2795050|1346133-08-1|LY-2795050|71PAL357HO|CHEMBL1921842|Benzamide, 3-chloro-4-(4-(((2S)-2-(3-pyridinyl)-1-pyrrolidinyl)methyl)phenoxy)-benzamide, 3-chloro-4-(4-(((2S)-2-(3-pyridinyl)-1-pyrrolidinyl)methyl)phenoxy)-|3-Chloro-4-[4-[[(2S)-2-pyridin-3-ylpy

英文名称：LY2795050

生化机理：DescriptionIC50 Value 0.72 nM (κ-opioid Receptor); 25.8 nM (κ-opioid) [1]LY2795050 is a novel selective KOR antagonist and has the potential as a PET tracer to image KOR in vivo.in vitro LY2795050 displays full antagonist activity and high binding affinity and selectivity for KOR with a ki value of 0.72 nM [1].in vivo In the brain, (11)C-LY2795050 displayed fast uptake kinetics (regional activity peak times of <20 min) and an uptake pattern consistent with the distribution of KOR in primates [1]. The LY2795050 ED50 at MOR was 119 μg/kg based on a 1-site model for 11C-carfentanil. The 1-site binding model was also deemed sufficient to describe the specific binding of 11C-LY2795050 at KOR. The ED50 at KOR estimated from the 1-site model was 15.6 μg/kg. Thus, the ED50 ratio for MORKOR was 7.6 [2].Clinical trial N/A

储存温度：-20°C储存

运输条件：超低温冰袋运输

IUPAC Name：3-chloro-4-[4-[[(2S)-2-pyridin-3-ylpyrrolidin-1-yl]methyl]phenoxy]benzamide

INCHI：InChI=1S/C23H22ClN3O2/c24-20-13-17(23(25)28)7-10-22(20)29-19-8-5-16(6-9-19)15-27-12-2-4-21(27)18-3-1-11-26-14-18/h1,3,5-11,13-14,21H,2,4,12,15H2,(H2,25,28)/t21-/m0/s1

InChi Key：LOOCZNLSXJHWTG-NRFANRHFSA-N

Canonical SMILES：C1CC(N(C1)CC2=CC=C(C=C2)OC3=C(C=C(C=C3)C(=O)N)Cl)C4=CN=CC=C4

Isomeric SMILES：C1C[C@H](N(C1)CC2=CC=C(C=C2)OC3=C(C=C(C=C3)C(=O)N)Cl)C4=CN=CC=C4

PubChem CID：56851583

溶解性：25°C DMSO

产品包装