产品名称

英文名称：Ambroxol HCl

同义词

Ambroxol hydrochloride、23828-92-4、Ambroxol HCl、Mucoangin、Mucosolvan、1384955-66-1、1146648-86-3、15942-05-9、Ambroxolhydrochloride、Lasolvan、4-((2-amino-3,5-dibromobenzyl)amino)cyclohexan-1-ol hydrochloride、trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexano、盐酸氨溴索、氨溴索 盐酸盐

产品性质

CAS编号：23828-92-4

分子式：C13H18Br2N2O·HCl

分子量：414.56

EC号：245-899-2

MDL号：MFCD00078932

PubChem编号：108013

别名：盐酸氨溴索|氨溴索 盐酸盐

英文别名：Ambroxol hydrochloride|23828-92-4|Ambroxol HCl|Mucoangin|Mucosolvan|1384955-66-1|1146648-86-3|15942-05-9|Ambroxolhydrochloride|Lasolvan|4-((2-amino-3,5-dibromobenzyl)amino)cyclohexan-1-ol hydrochloride|trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexano

规格或纯度：≥99%

英文名称：Ambroxol HCl

生化机理：Ambroxol hydrochloride is a small molecule expectorant and mucolytic agent with antioxidant and antiinflammatory effects. Ambroxol stimulates the secretion of surfactant which decreases mucus adhesion to the bronchial lining and produces expectorant effects. The antioxidant effects of Ambroxol are well demonstrated, where lipid peroxidation initiated by t-butyl hydroperoxide or doxorubicin is suppressed in the presence Ambroxol, and scavenging of hydroxyl radicals and cellular superoxide radical anions is also observed. Ambroxol produces antiinflammatory effects by blocking the expression of proinflammatory messengers, inhibiting the release of histamine from mast cells and the generation of cytokines and interleukins. Ambroxol hydrochloride is an inhibitor of Sodium Channel Protein.Antioxidant, anti-inflammatory agent. Na+ channel blocker and mucolytic agent. Stimulates surfactant secretion and produces expectorant effects by decreasing mucus adhesion to the bronchial lining. Inhibits histamine secretion from mast cells.

应用：An expectorant antioxidant and antiinflammatory agent

运输条件：常规运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Ambroxol HCl是有效的神经性钠离子通道抑制剂，抑制抗TTX的钠离子电流，相位性阻滞，IC50为22.5 μM，抑制对TTX敏感的钠离子电流，IC50为100 μM。Phase 3。An expectorant antioxidant and antiinflammatory agentAmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Phase 3.An expectorant antioxidant and antiinflammatory agent

PubChem SID：488187420

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488187420

IUPAC Name：4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol;hydrochloride

INCHI：InChI=1S/C13H18Br2N2O.ClH/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10;/h5-6,10-11,17-18H,1-4,7,16H2;1H

InChi Key：QNVKOSLOVOTXKF-UHFFFAOYSA-N

Canonical SMILES：C1CC(CCC1NCC2=C(C(=CC(=C2)Br)Br)N)O.Cl

Isomeric SMILES：C1CC(CCC1NCC2=C(C(=CC(=C2)Br)Br)N)O.Cl

RTECS：GV8425000

关联CAS：18683-91-5

PubChem CID：108013

Reaxy-Rn：4894348

溶解性：Soluble in methanol, water (~5 mg/ml), ethanol (~5 mg/ml), and DMSO (50 mM). Insoluble in ether.

熔点：235°C(dec.)(lit.)

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

Merck Index：386

产品包装