产品名称

英文名称：Stavudine (d4T)

同义词

stavudine、3056-17-5、sanilvudine、Zerit、2',3'-Didehydro-3'-deoxythymidine、Stavudinum、Zerit Xr、Estavudina、d4T、BMY-27857、Thymidine, 2',3'-didehydro-3'-deoxy-、Stavudinum [INN-Latin]、Estavudina [INN-Spanish]、3'-Deoxy-2'-thymidinene、2',3'-Didehydro-3'-deoxythimi、司他呋啶、司他夫定、2',3'-二脱氢-3'-脱氧胸苷、1-(2,3-二脱氧-β-D-丙三基-2-戊烯呋喃酮基)胸腺嘧啶

产品性质

CAS编号：3056-17-5

分子式：C10H12N2O4

分子量：224.21

MDL号：MFCD00132921

PubChem编号：18283

别名：司他呋啶|司他夫定|2',3'-二脱氢-3'-脱氧胸苷|1-(2,3-二脱氧-β-D-丙三基-2-戊烯呋喃酮基)胸腺嘧啶

英文别名：stavudine|3056-17-5|sanilvudine|Zerit|2',3'-Didehydro-3'-deoxythymidine|Stavudinum|Zerit Xr|Estavudina|d4T|BMY-27857|Thymidine, 2',3'-didehydro-3'-deoxy-|Stavudinum [INN-Latin]|Estavudina [INN-Spanish]|3'-Deoxy-2'-thymidinene|2',3'-Didehydro-3'-deoxythimi

规格或纯度：≥98%

英文名称：Stavudine (d4T)

生化机理：3'-Deoxy-2',3'-didehydrothymidine is a HIV-1 RT (HIV reverse transcriptase) inhibitor that causes a consistent and rapid shortening of telomeres in Tetrahymera. 3'-Deoxy-2',3'-didehydrothymidine has been shown to decrease the proliferative activity of Jurkat and L1210 cell lines as well as human peripheral blood mononuclear cells at 250 μM concentration.Thymidine analog. Reverse-transcriptase inhibitor. Antiretroviral agent. Inhibits constitutive and induced autophagic activity in adipocytes. Inhibits HIV replication in vivo. Orally active.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Stavudine (d4T)是一种核苷类似物逆转录酶抑制剂（NARTI），有效作用于HIV。A HIV reverse transcriptase (HIV-1 RT) inhibitorStavudine (d4T) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV.A HIV reverse transcriptase (HIV-1 RT) inhibitor

PubChem SID：488182454

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488182454

IUPAC Name：1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-dione

INCHI：InChI=1S/C10H12N2O4/c1-6-4-12(10(15)11-9(6)14)8-3-2-7(5-13)16-8/h2-4,7-8,13H,5H2,1H3,(H,11,14,15)/t7-,8+/m0/s1

InChi Key：XNKLLVCARDGLGL-JGVFFNPUSA-N

Canonical SMILES：CC1=CN(C(=O)NC1=O)C2C=CC(O2)CO

Isomeric SMILES：CC1=CN(C(=O)NC1=O)[C@H]2C=C[C@H](O2)CO

WGK Germany：2

RTECS：XP2075000

PubChem CID：18283

Reaxy-Rn：618327

溶解性：Soluble in DMSO, methanol, water (83 mg/ml) at 23 °C, chloroform, ethanol, and propylene glycol (30 mg/mL) at 23 °C.

比旋光度：-46° (C=0.69,H2O)

熔点：166°C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH341 Suspected of causing genetic defectsH302 Harmful if swallowedH372 Causes damage to organs through prolonged or repeated exposureH361 Suspected of damaging fertility or the unborn childH362 May cause harm to breast-fed children

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P260,P281,P271,P270,P304+P340,P403+P233,P362+P364,P330,P263,P203,P264+P265,P301+P317,P318,P337+P317,P332+P317,P319

个人防护装备：Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

产品包装