产品名称

英文名称：S-(5′-Adenosyl)-L-homocysteine

同义词

S-adenosylhomocysteine、S-adenosyl-L-homocysteine、979-92-0、AdoHcy、S-(5'-adenosyl)-L-homocysteine、S-(5'-deoxyadenosin-5'-yl)-L-homocysteine、adenosylhomocysteine、Formycinylhomocysteine、5'-Deoxy-S-adenosyl-L-homocysteine、Adenosyl-L-homocysteine、L-Homocysteine、S-腺苷-L-高半胱氨酸、S-(5'-腺苷)-L-高半胱氨酸、5'-脱氧-S-腺苷-L-高半胱氨酸、S-(5'-脱氧腺苷-5')-L-高半胱氨酸

产品性质

CAS编号：979-92-0

分子式：C14H20N6O5S

分子量：384.41

Beilstein号：99188

EC号：213-560-8

MDL号：MFCD00037388

PubChem编号：439155

别名：S-腺苷-L-高半胱氨酸|S-(5'-腺苷)-L-高半胱氨酸|5'-脱氧-S-腺苷-L-高半胱氨酸|S-(5'-脱氧腺苷-5')-L-高半胱氨酸

英文别名：S-adenosylhomocysteine|S-adenosyl-L-homocysteine|979-92-0|AdoHcy|S-(5'-adenosyl)-L-homocysteine|S-(5'-deoxyadenosin-5'-yl)-L-homocysteine|adenosylhomocysteine|Formycinylhomocysteine|5'-Deoxy-S-adenosyl-L-homocysteine|Adenosyl-L-homocysteine|L-Homocysteine

规格或纯度：≥98%

英文名称：S-(5′-Adenosyl)-L-homocysteine

生化机理：S-(5′-Adenosyl)-L-homocysteine (AdoHcy/SAH) is a component of intracellular homocysteine stress. AdoHcy is a competitive inhibitor (versus AdoMet) of DNA methyltransferases (S-adenosyl-L-methionine (AdoMet)-dependent methyltransferases) involved in epigenetics. Consequently, AdoHcy is used in a variety of studies on epigenetics in hyperhomocysteinemic states. AdoHcy is metabolized by S-adenosylhomocysteine hydrolase (AHCY). AdoHcy is the product of enzymatic transmethylation reactions involving S-Adenosylmethionine (SAM). It is reconverted to SAM by its cleavage into adenosine and L-homocysteine, a substrate of thetin-homocysteine S-methyltransferase. The concentration alterations of SAM and SAH in plasma serve as predictors of cellular methylation potential and metabolic alterations. Methylation capacity indicates specific genetic polymorphisms and/or nutritional deficiencies. Methylation is important in epigenetics, reprogramming, and cancer.

储存温度：避光,-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：SAH 是氨基酸衍生物和几种代谢途径中的调节剂。 它是半胱氨酸和腺苷合成的中间体。SAH 是 METTL3-METTL14 异二聚体复合物 (METTL3-14) 的抑制剂，IC50 为 0.9 µM。SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM.applicationSAH is suitable for useto investigate whether AdoHcy competes with AdoMet in the down-regulation of reporter activity of LUC reporter geneas a reagent to study the abundance patterns of SAH and its correlation with vertebrate metamorphosisin the optimization of the protein (lysine K) methyltransferase SET7/9 activity assayin the fluorescence polarization (FP) assay during dengue virus methyltransferase activity measurementas a standard for the measurement of SAH from blood samples by high performance liquid chromatography (HPLC) with fluorimetric detection method

PubChem SID：488189734

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488189734

IUPAC Name：(2S)-2-amino-4-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]butanoic acid

INCHI：InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1

InChi Key：ZJUKTBDSGOFHSH-WFMPWKQPSA-N

Canonical SMILES：C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)CSCCC(C(=O)O)N)O)O)N

Isomeric SMILES：C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CSCC[C@@H](C(=O)O)N)O)O)N

PubChem CID：439155

CAS Registry No.：979-92-0

Wikipedia：S-adenosylhomocysteine

ChEBI：CHEBI16680

DrugBank Ligand：DB01752

ChEMBL Ligand：CHEMBL418052

RCSB PDB Ligand：SAH

溶解性：DMSO 130 mg/mL (338.18 mM；Need ultrasonic)

敏感性：对光敏感

产品包装