产品名称

英文名称：Pentostatin

同义词

pentostatin、Deoxycoformycin、Nipent、2'-Deoxycoformycin、53910-25-1、CO-Vidarabine、Covidarabine、PD-ADI、Pentostatina、Pentostatine、Pentostatinum、2'-DCF、CI-825、YK-176、Vidarbine、(R)-2'-Deoxycoformycin、NSC-218321、(R)-Deoxycoformycin、PD 81565、PD-81565、8R-2'-Deoxyco、CI-825、腺苷脱氨酶抑制剂、2ʹ-脱氧助间型霉素、(8R)-3-(2-脱氧基-β-D-赤呋喃戊糖基)-3,6,7,8-四氢咪唑并[4,5-d][1,3]二氮革-8-醇、抗生链霉菌

产品性质

CAS编号：53910-25-1

分子式：C11H16N4O4

分子量：268.27

PubChem编号：439693

别名：CI-825|腺苷脱氨酶抑制剂|2ʹ-脱氧助间型霉素|(8R)-3-(2-脱氧基-β-D-赤呋喃戊糖基)-3,6,7,8-四氢咪唑并[4,5-d][1,3]二氮革-8-醇|抗生链霉菌

英文别名：pentostatin|Deoxycoformycin|Nipent|2'-Deoxycoformycin|53910-25-1|CO-Vidarabine|Covidarabine|PD-ADI|Pentostatina|Pentostatine|Pentostatinum|2'-DCF|CI-825|YK-176|Vidarbine|(R)-2'-Deoxycoformycin|NSC-218321|(R)-Deoxycoformycin|PD 81565|PD-81565|8R-2'-Deoxyco

规格或纯度：98%(HPLC)

英文名称：Pentostatin

生化机理：Pentostatin(Deoxycoformycin) is a irreversible inhibitor of adenosine deaminase (Ki = 2.5 pM). Pentostatin (Deoxycoformycin) is useful for anticancer agent.Potent, irreversible, cell-permeable adenosine deaminase inhibitor (K i = 0.9 pM)\xa0which interrupts DNA synthesis in dividing cells. Purine analog reported to exert selective toxicity towards lymphocytes. Anticancer agent.

储存温度：避光,-20°C储存,充氩

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Pentostatin is a ring-expanded nucleoside (REN) that potently inhibits adenosine deaminase inhibitor, which leads to lymphocyte toxicity. Pentostatin is used as anticancer agent to treat leukemia (hairy cell leukemia and chronic lymphocytic leukemia) and is investigated as an agent to treat graft-versus-host disease (GVHD)

ALogP：-2.1

IUPAC Name：(8R)-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-7,8-dihydro-4H-imidazo[4,5-d][1,3]diazepin-8-ol

INCHI：InChI=1S/C11H16N4O4/c16-3-8-6(17)1-9(19-8)15-5-14-10-7(18)2-12-4-13-11(10)15/h4-9,16-18H,1-3H2,(H,12,13)/t6-,7+,8+,9+/m0/s1

InChi Key：FPVKHBSQESCIEP-JQCXWYLXSA-N

Canonical SMILES：C1C(C(OC1N2C=NC3=C2NC=NCC3O)CO)O

Isomeric SMILES：C1[C@@H]([C@H](O[C@H]1N2C=NC3=C2NC=NC[C@H]3O)CO)O

WGK Germany：3

PubChem CID：439693

DrugBank Ligand：DB00552

Wikipedia：Pentostatin

CAS Registry No.：53910-25-1

ChEMBL Ligand：CHEMBL1580

RCSB PDB Ligand：DCF

DrugCentral Ligand：2098

敏感性：对空气敏感；易吸湿；对光敏感

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowed

预防措施声明：P321,P405,P501,P264,P270,P330,P301+P316

产品包装