产品名称

英文名称：Aleglitazar

同义词

DB08915 、 RO7 、 SMR000024554 、 BDBM50277897 、 DTXSID70197193 、 R 1439 、 BENZO(B)THIOPHENE-7-PROPANOIC ACID, .ALPHA.-METHOXY-4-(2-(5-METHYL-2-PHENYL-4-OXAZOLYL)ETHOXY)-, (.ALPHA.S)- 、 D08845 、 (2S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethox、阿格列扎

产品性质

CAS编号：475479-34-6

分子式：C24H23NO5S

分子量：437.51

PubChem编号：10274777

别名：阿格列扎

英文别名：DB08915 | RO7 | SMR000024554 | BDBM50277897 | DTXSID70197193 | R 1439 | BENZO(B)THIOPHENE-7-PROPANOIC ACID, .ALPHA.-METHOXY-4-(2-(5-METHYL-2-PHENYL-4-OXAZOLYL)ETHOXY)-, (.ALPHA.S)- | D08845 | (2S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethox

规格或纯度：≥98%

英文名称：Aleglitazar

生化机理：Aleglitazar (R1439) is a dual peroxisome proliferator-activated receptor (PPAR) agonist, with affinity to PPARα and PPARγ. Aleglitazar is being developed for the treatment of type II diabetes; It is currently in phase III clinical trials. In preliminary clinical studies, Aleglitazar has been demonstrated to improve hyperglycemia and dyslipidemia in patients with type 2 diabetes mellitus. Aleglitazar has beneficial effects on both lipid and glucose parameters and may have a therapeutic role in modifying cardiovascular risk factors and improving glycemic control in patients with T2DM. Aleglitazar combines the lipid benefits of fibrates and the insulin-sensitizing benefits of thiazolidinediones.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Aleglitazar (R1439;RO0728804) 是一种高效的 PPARα/γ 双重激动剂，对人 PPARα 和 PPARγ 作用的 IC50 分别为 38 nM 和 19 nM。Aleglitazar 可用于 II 型糖尿病的研究。 Aleglitazar (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively. Aleglitazar can be used for the research of type II diabetes。

ALogP：5.1

IUPAC Name：(2S)-2-methoxy-3-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl]propanoic acid

INCHI：InChI=1S/C24H23NO5S/c1-15-19(25-23(30-15)16-6-4-3-5-7-16)10-12-29-20-9-8-17(14-21(28-2)24(26)27)22-18(20)11-13-31-22/h3-9,11,13,21H,10,12,14H2,1-2H3,(H,26,27)/t21-/m0/s1

InChi Key：DAYKLWSKQJBGCS-NRFANRHFSA-N

Canonical SMILES：CC1=C(CCOC2=CC=C(C[C@@H](C(O)=O)OC)C3=C2C=CS3)N=C(C4=CC=CC=C4)O1

Isomeric SMILES：CC1=C(N=C(O1)C2=CC=CC=C2)CCOC3=C4C=CSC4=C(C=C3)C[C@@H](C(=O)O)OC

PubChem CID：10274777

ChEMBL Ligand：CHEMBL519504

DrugBank Ligand：DB08483

Wikipedia：Aleglitazar

CAS Registry No.：475479-34-6

RCSB PDB Ligand：RO7

溶解性：DMSO

产品包装