产品名称

英文名称：Inolitazone

同义词

UNII-M17ILL71MC、CHEBI168130、FT-0737589、5-[4-[6-(4-amino-3 ,5-dimethylphenoxy)-1-methyl-1H-benzimidazol-2-ylmethoxy]benzyl]thiazolidine-2,4-dione、Q21083321、BDBM50450236、(cis) 3,3,5-trimethylcyclohexanol、5-(4-{[6-(4-amino-3,5-dimethylphenoxy)-1-methyl-1-H-、伊诺他酮

产品性质

CAS编号：223132-37-4

分子式：C27H26N4O4S

分子量：502.58

PubChem编号：9832447

别名：伊诺他酮

英文别名：UNII-M17ILL71MC|CHEBI168130|FT-0737589|5-[4-[6-(4-amino-3 ,5-dimethylphenoxy)-1-methyl-1H-benzimidazol-2-ylmethoxy]benzyl]thiazolidine-2,4-dione|Q21083321|BDBM50450236|(cis) 3,3,5-trimethylcyclohexanol|5-(4-{[6-(4-amino-3,5-dimethylphenoxy)-1-methyl-1-H-

规格或纯度：≥98%

英文名称：Inolitazone

生化机理：The IC50 for growth inhibition is approximately 0.8 nM while anaplastic thyroid carcinoma (ATC) tumor growth was inhibited three- to fourfold in nude mice. siRNA against PPARgamma and a pharmacological antagonist demonstrated that functional PPARgamma was required for growth inhibitory activity of RS5444. RS5444 upregulated the cell cycle kinase inhibitor, p21WAF1/CIP1 . RS5444inhibited culture growth and caused irreversible G1 arrest, but did not induce apoptosis. In addition, RS5444 caused dramatic changes in cellular morphology which were associated with increased motility and diminished cellular adherence, but no increase in the ability of such cells to digest and invade Matrigel . Treatment with RS5444 leads to the up-regulation of RhoB and subsequent activation of p21, and that silencing of RhoB by RNAi blocks the ability of RS5444 to induce p21 and to inhibit ATC cells proliferation.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Inolitazone(RS5444; CS-7017)是新型PPARγ高亲和性激动剂，EC50为rosiglitazone的五十分之一，对于不表达PPARγ的RIE细胞无抑制性。Inolitazone(RS5444; CS-7017) is a novel high-affinity PPARγ agonist, which activates PPARγ with an EC50 about 1/50 that of rosiglitazone and has no effect on RIE cells that do not express PPARγ.

IUPAC Name：5-[[4-[[6-(4-amino-3,5-dimethylphenoxy)-1-methylbenzimidazol-2-yl]methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione

INCHI：InChI=1S/C27H26N4O4S/c1-15-10-20(11-16(2)25(15)28)35-19-8-9-21-22(13-19)31(3)24(29-21)14-34-18-6-4-17(5-7-18)12-23-26(32)30-27(33)36-23/h4-11,13,23H,12,14,28H2,1-3H3,(H,30,32,33)

InChi Key：JCYNMRJCUYVDBC-UHFFFAOYSA-N

Canonical SMILES：CC1=CC(=CC(=C1N)C)OC2=CC3=C(C=C2)N=C(N3C)COC4=CC=C(C=C4)CC5C(=O)NC(=O)S5

Isomeric SMILES：CC1=CC(=CC(=C1N)C)OC2=CC3=C(C=C2)N=C(N3C)COC4=CC=C(C=C4)CC5C(=O)NC(=O)S5

PubChem CID：9832447

溶解性：DMSO

产品包装