产品名称

英文名称：Pepstatin

同义词

Pepstatin A、pepstatin、26305-03-3、Pepstatine、Ahpatinin C、Pepstatinum、Pepstatina、Pepsin inhibitor S 735A、Procidin S 735A、Pepstatin (nonspecific)、Pepstatin (VAN)、CCRIS 3603、Iva-Val-Val-Sta-Ala-Sta-OH、MLS002222329、CHEMBL296588、V6Y2T27Q1U、DTXSID7046095、39324-3、抑肽素、胃酶抑素 A

产品性质

CAS编号：26305-03-3

分子式：C34H63N5O9

分子量：685.9

Beilstein号：2201362

EC号：247-600-0

MDL号：MFCD00060740

PubChem编号：5478883

别名：抑肽素|胃酶抑素 A

英文别名：Pepstatin A|pepstatin|26305-03-3|Pepstatine|Ahpatinin C|Pepstatinum|Pepstatina|Pepsin inhibitor S 735A|Procidin S 735A|Pepstatin (nonspecific)|Pepstatin (VAN)|CCRIS 3603|Iva-Val-Val-Sta-Ala-Sta-OH|MLS002222329|CHEMBL296588|V6Y2T27Q1U|DTXSID7046095|39324-3

规格或纯度：≥75% (HPLC)

英文名称：Pepstatin

生化机理：Pepstatin A is an inhibitor of acid proteases (aspartyl peptidases). It forms a 11 complex with proteases such as pepsin, renin, cathepsin D, bovine chymosin, and protease B (Aspergillus niger). The inhibitor is highly selective and does not inhibit thiol proteases, neutral proteases, or serine proteases. Solubilized γ-secretase and retroviral protease are also inhibited by Pepstatin A. It has been used to characterize proteases from several sources.Potent and selective aspartic protease inhibitor. Forms a 11 complex with pepsin, renin, cathepsins D and E. Inhibits solubilized γ-secretase and retroviral protease. Active in vivo.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，这些产品最多可以使用一周。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Can be used in conjunction with E64-d and Leupeptin A to inhibit the degradation of autophagic cargo inside autophagosomes. For this application, the working concentration is typically between 1-10 μM.An inhibitor of HIV-1 and aspartic proteases. Pepstatin A inhibits the aspartic proteases cathepsin D, pepsin, and renin. Additionally, it suppresses p53-dependent apoptosis in lymphoid cells as well as TNFα-induced apoptosis in U937 cells. Pepstatin A also efficiently inhibits HIV-1 protease and Fcγ receptor induction by IFN-γ.Can be used in conjunction with E64-d and Leupeptin A to inhibit the degradation of autophagic cargo inside autophagosomes. For this application, the working concentration is typically between 1-10 μM.An inhibitor of HIV-1 and aspartic proteases. Pepstatin A inhibits the aspartic proteases cathepsin D, pepsin, and renin. Additionally, it suppresses p53-dependent apoptosis in lymphoid cells as well as TNFα-induced apoptosis in U937 cells. Pepstatin A also efficiently inhibits HIV-1 protease and Fcγ receptor induction by IFN-γ.

IUPAC Name：(3S,4S)-3-hydroxy-4-[[(2S)-2-[[(3S,4S)-3-hydroxy-6-methyl-4-[[(2S)-3-methyl-2-[[(2S)-3-methyl-2-(3-methylbutanoylamino)butanoyl]amino]butanoyl]amino]heptanoyl]amino]propanoyl]amino]-6-methylheptanoic acid

INCHI：InChI=1S/C34H63N5O9/c1-17(2)12-23(37-33(47)31(21(9)10)39-34(48)30(20(7)8)38-27(42)14-19(5)6)25(40)15-28(43)35-22(11)32(46)36-24(13-18(3)4)26(41)16-29(44)45/h17-26,30-31,40-41H,12-16H2,1-11H3,(H,35,43)(H,36,46)(H,37,47)(H,38,42)(H,39,48)(H,44,45)/t22-,23-,24-,25-,26-,30-,31-/m0/s1

InChi Key：FAXGPCHRFPCXOO-LXTPJMTPSA-N

Canonical SMILES：CC(C)CC(C(CC(=O)O)O)NC(=O)C(C)NC(=O)CC(C(CC(C)C)NC(=O)C(C(C)C)NC(=O)C(C(C)C)NC(=O)CC(C)C)O

Isomeric SMILES：C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)O)O)NC(=O)C[C@@H]([C@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)CC(C)C)O

WGK Germany：2

RTECS：SC6155000

PubChem CID：5478883

溶解性：Soluble in 10% (v/v) acetic acid in methanol (91 methanolacetic acid) (1 mg/ml), ethanol (1-2 mg/ml with heat up to 60 °C), DMSO (5 mg/ml), methanol (1 mg/ml), and acetic acid. Insoluble in benzene, chloroform, water, 1 M NaOH, and ether.

密度：1.117

敏感性：对热敏感

熔点：232 - 237 °C

象形图：

信号词：Danger

危险声明：H300 Fatal if swallowed

预防措施声明：P321,P405,P501,P264,P270,P330,P301+P316

个人防护装备：Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

产品包装