产品名称

英文名称：PF-04217903

同义词

PF-04217903、956905-27-4、PF04217903、1159490-85-3、2-(4-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol、PF 04217903、PF-4217903、CYJ9ATV1IJ、Met tyrosine kinase inhibitor PF-04217903、CHEMBL2001019、2-[4-[3-(quinolin-6-ylme

产品性质

CAS编号：956905-27-4

分子式：C19H16N8O

分子量：372.38

PubChem编号：17754438

英文别名：PF-04217903|956905-27-4|PF04217903|1159490-85-3|2-(4-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol|PF 04217903|PF-4217903|CYJ9ATV1IJ|Met tyrosine kinase inhibitor PF-04217903|CHEMBL2001019|2-[4-[3-(quinolin-6-ylme

规格或纯度：≥98%

英文名称：PF-04217903

生化机理：PF-04217903 is a selective ATP-competitive Met inhibitor (IC50 = 4.8 nM).

应用：A selective ATP-competitive Met inhibitor.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：5mg、10mg卖完停产，不再备货

产品介绍：PF-04217903是一种选择性的，ATP竞争性c-Met抑制剂，IC50为4.8 nM，对致癌基因突变型敏感(对Y1230C突变型没有活性)。A selective ATP-competitive Met inhibitor.PF-04217903 is a selective ATP-competitive c-Met inhibitor with IC50 of 4.8 nM, susceptible to oncogenic mutations (no activity to Y1230C mutant).A selective ATP-competitive Met inhibitor.

ALogP：0.7

IUPAC Name：2-[4-[3-(quinolin-6-ylmethyl)triazolo[4,5-b]pyrazin-5-yl]pyrazol-1-yl]ethanol

INCHI：InChI=1S/C19H16N8O/c28-7-6-26-12-15(9-22-26)17-10-21-18-19(23-17)27(25-24-18)11-13-3-4-16-14(8-13)2-1-5-20-16/h1-5,8-10,12,28H,6-7,11H2

InChi Key：PDMUGYOXRHVNMO-UHFFFAOYSA-N

Canonical SMILES：C1=CC2=C(C=CC(=C2)CN3C4=NC(=CN=C4N=N3)C5=CN(N=C5)CCO)N=C1

Isomeric SMILES：C1=CC2=C(C=CC(=C2)CN3C4=NC(=CN=C4N=N3)C5=CN(N=C5)CCO)N=C1

PubChem CID：17754438

溶解性：Soluble in DMSO (5 mg/mL at 25 °C), water (<1 mg/mL at 25 °C), and ethanol (<1 mg/mL at 25 °C).

产品包装