产品名称

英文名称：CPI-613

同义词

CPI-613、95809-78-2、6,8-bis(benzylthio)octanoic acid、Devimistat、CPI 613、6,8-Bis(benzylsulfanyl)octanoic acid、CPI613、MLS006010202、SCHEMBL1062218、MFCD22420826、E76113IR49、6,8-Bis[(phenylmethyl)thio]octanoic acid、Octanoic acid, 6,8-bis((phenylmethyl)thio)-、Oct、6,8-双(苄硫基)辛酸

产品性质

CAS编号：95809-78-2

分子式：C22H28O2S2

分子量：388.59

MDL号：MFCD22420826

PubChem编号：24770514

别名：6,8-双(苄硫基)辛酸

英文别名：CPI-613|95809-78-2|6,8-bis(benzylthio)octanoic acid|Devimistat|CPI 613|6,8-Bis(benzylsulfanyl)octanoic acid|CPI613|MLS006010202|SCHEMBL1062218|MFCD22420826|E76113IR49|6,8-Bis[(phenylmethyl)thio]octanoic acid|Octanoic acid, 6,8-bis((phenylmethyl)thio)-|Oct

规格或纯度：≥98%

英文名称：CPI-613

生化机理：CPI-613 is a racemic mixture of the enantiomers of a synthetic alpha-lipoic lipoic acid analogue with potential chemopreventive and antineoplastic activities. CPI-613 is an E1α pyruvate dehydrogenase (PDH) modulator that prevents cancer cells from metabolizing glucose for energy. CPI-613 has been granted orphan drμg status by the US FDA for pancreatic cancer.Tumor-selective α-ketoglutarate dehydrogenase inhibitor. Antitumor agent. Induces apoptotic and non-apoptotic cell death in tumor cell lines. Induces mitochondrial redox signal and loss of cell membrane potential. Lipoate analog. Shows potent antitumor ef

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：CPI-613是Lipoate类似物，能抑制丙酮酸脱氢酶（PDH）和α-酮戊二酸脱氢酶。CPI-613 is an E1α pyruvate dehydrogenase (PDH) modulator that prevents cancer cells from metabolizing glucose for energy. CPI-613 has been granted orphan drug status by the US FDA for pancreatic cancer.

IUPAC Name：6,8-bis(benzylsulfanyl)octanoic acid

INCHI：InChI=1S/C22H28O2S2/c23-22(24)14-8-7-13-21(26-18-20-11-5-2-6-12-20)15-16-25-17-19-9-3-1-4-10-19/h1-6,9-12,21H,7-8,13-18H2,(H,23,24)

InChi Key：ZYRLHJIMTROTBO-UHFFFAOYSA-N

Canonical SMILES：C1=CC=C(C=C1)CSCCC(CCCCC(=O)O)SCC2=CC=CC=C2

Isomeric SMILES：C1=CC=C(C=C1)CSCCC(CCCCC(=O)O)SCC2=CC=CC=C2

WGK Germany：3

PubChem CID：24770514

溶解性：DMSO 78 mg/mL Water <1 mg/mL Ethanol 78 mg/mL

熔点：70 °C

象形图：

危险声明：H410 Very toxic to aquatic life with long lasting effects

预防措施声明：P273,P501

产品包装