产品名称

英文名称：Talarozole

同义词

Talarozole、201410-53-9、Rambazole、R115866、R-115866、N-(4-(2-ethyl-1-(1H-1,2,4-triazol-1-yl)butyl)phenyl)benzo[d]thiazol-2-amine、201410-66-4、(+)-Talarozole、XKD9N5CJ6W、N-[4-[2-ethyl-1-(1,2,4-triazol-1-yl)butyl]phenyl]-1,3-benzothiazol-2-amine、CHEMBL459505、2-B

产品性质

CAS编号：201410-53-9

分子式：C21H23N5S

分子量：377.51

PubChem编号：9799888

英文别名：Talarozole|201410-53-9|Rambazole|R115866|R-115866|N-(4-(2-ethyl-1-(1H-1,2,4-triazol-1-yl)butyl)phenyl)benzo[d]thiazol-2-amine|201410-66-4|(+)-Talarozole|XKD9N5CJ6W|N-[4-[2-ethyl-1-(1,2,4-triazol-1-yl)butyl]phenyl]-1,3-benzothiazol-2-amine|CHEMBL459505|2-B

规格或纯度：≥99%

英文名称：Talarozole

生化机理：Description IC50 ValueN/A Talarozole is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid for the treatment of psoriasis and acne[2]. in vitro Talarozole treatment increased the mRNA expression of CRABP2, KRT4, CYP26A1 and CYP26B1 dose dependently, and decreased theexpression of KRT2 and IL-1alpha compared with vehicle-treated skin. No mRNA change in retinol-metabolizing enzymes was obtained. There was no induction of epidermal thickness or overt skin inflammation in talarozole-treated skin. Immunofluorescence analysis confirmed an upregulation of KRT4 protein, but no upregulation of CYP26A1 and CYP26B1 expression was detected [1]. in vivo Talarozole slightly diffused into the skin only when dissolved in propylene glycol, isopropyl myristate or ethanol. Althoμgh only 0.1% of the dose applied was found in the skin itself after 12-24 h, this was sufficient to achieve local concentrations well above the hal

储存温度：-20°C储存

运输条件：超低温冰袋运输

ALogP：6

IUPAC Name：N-[4-[2-ethyl-1-(1,2,4-triazol-1-yl)butyl]phenyl]-1,3-benzothiazol-2-amine

INCHI：InChI=1S/C21H23N5S/c1-3-15(4-2)20(26-14-22-13-23-26)16-9-11-17(12-10-16)24-21-25-18-7-5-6-8-19(18)27-21/h5-15,20H,3-4H2,1-2H3,(H,24,25)

InChi Key：SNFYYXUGUBUECJ-UHFFFAOYSA-N

Canonical SMILES：CCC(CC)C(C1=CC=C(C=C1)NC2=NC3=CC=CC=C3S2)N4C=NC=N4

Isomeric SMILES：CCC(CC)C(C1=CC=C(C=C1)NC2=NC3=CC=CC=C3S2)N4C=NC=N4

PubChem CID：9799888

CAS Registry No.：201410-53-9

ChEMBL Ligand：CHEMBL459505

BindingDB Ligand：50253810

DrugBank Ligand：DB13083

溶解性：25°C DMSO

产品包装