产品名称

英文名称：AZD7687

同义词

AZD7687、1166827-44-6、AZD-7687、AZD 7687、6QTJ9P2NYT、UNII-6QTJ9P2NYT、CHEMBL2178944、CHEMBL2178953、{4-[4-(6-Carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]cyclohexyl}acetic acid、2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]cyclohexyl]acetic acid、2-((1s,4s)-

产品性质

CAS编号：1166827-44-6

分子式：C21H25N3O3

分子量：367.44

PubChem编号：42636350

英文别名：AZD7687|1166827-44-6|AZD-7687|AZD 7687|6QTJ9P2NYT|UNII-6QTJ9P2NYT|CHEMBL2178944|CHEMBL2178953|{4-[4-(6-Carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]cyclohexyl}acetic acid|2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]cyclohexyl]acetic acid|2-((1s,4s)-

规格或纯度：98%

英文名称：AZD7687

生化机理：The attenuating effect of AZD7687, the selective DGAT1 inhibitor, on postprandial triacylglycerol (TAG) excursion provides proof of mechanism with respect to gut DGAT1 inhibition. Nausea, vomiting and diarrhoea were reported with increasing doses and they limited dose escalation. Lowering of SMM fat content to 45 or 30% in five cohorts gradually reduced the frequency of gastrointestinal symptoms at a given dose of AZD7687.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：AZD7687 是一种有效的，选择性的，可逆的和具有活性的二酰基甘油酰基转移酶 1 (DGAT1) 抑制剂，对人 DGAT1 的 IC50 为 80 nM。AZD7687 可用于 2 型糖尿病和肥胖症研究。

IUPAC Name：2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]cyclohexyl]acetic acid

INCHI：InChI=1S/C21H25N3O3/c1-12-19(24-20(21(22)27)13(2)23-12)17-9-7-16(8-10-17)15-5-3-14(4-6-15)11-18(25)26/h7-10,14-15H,3-6,11H2,1-2H3,(H2,22,27)(H,25,26)

InChi Key：YXFNPRHZMOGREC-UHFFFAOYSA-N

Canonical SMILES：CC1=C(N=C(C(=N1)C)C(=O)N)C2=CC=C(C=C2)C3CCC(CC3)CC(=O)O

Isomeric SMILES：CC1=C(N=C(C(=N1)C)C(=O)N)C2=CC=C(C=C2)C3CCC(CC3)CC(=O)O

PubChem CID：42636350

ChEMBL Ligand：CHEMBL2178953

CAS Registry No.：1166827-44-6

溶解性：DMSO

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

产品包装