产品名称

英文名称：Tanaproget

同义词

Tanaproget、304853-42-7、NSP-989、5-(4,4-Dimethyl-2-thioxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)-1-methyl-1H-pyrrole-2-carbonitrile、W9F9H8GXWR、5-(4,4-dimethyl-2-sulfanylidene-1H-3,1-benzoxazin-6-yl)-1-methylpyrrole-2-carbonitrile、1H-Pyrrole-2-carbonitrile, 5-(

产品性质

CAS编号：304853-42-7

分子式：C16H15N3OS

分子量：297.37

PubChem编号：4369524

英文别名：Tanaproget|304853-42-7|NSP-989|5-(4,4-Dimethyl-2-thioxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)-1-methyl-1H-pyrrole-2-carbonitrile|W9F9H8GXWR|5-(4,4-dimethyl-2-sulfanylidene-1H-3,1-benzoxazin-6-yl)-1-methylpyrrole-2-carbonitrile|1H-Pyrrole-2-carbonitrile, 5-(

规格或纯度：≥99%

英文名称：Tanaproget

生化机理：DescriptionIC50 Value 0.1 nM (EC50, induce alkaline phosphatase activity) [1]Tanaproget is a novel nonsteroidal progesterone receptor agonist which can bind to the PR from various species with a higher relative affinity than reference steroidal progestins. Tanaproget represents a potential first-in-class nonsteroidal PR agonist for contraception with improved safety and side effect profiles versus currently available steroidal oral contraceptives.in vitro In T47D cells, TNPR induces alkaline phosphatase activity with an EC(50) value of 0.1 nm, comparable with potent steroidal progestins such as medroxyprogesterone acetate (MPA) and trimegestone (TMG), albeit with a reduced efficacy ( approximately 60%). In a mammalian two-hybrid assay to measure PR agonist-induced interaction between steroid receptor co-activator-1 and PR, TNPR showed similar potency (EC(50) value of 0.02 nm) and efficacy to MPA and TMG [1].in vivo TNPR effectively down-regu

储存温度：-20°C储存

运输条件：超低温冰袋运输

IUPAC Name：5-(4,4-dimethyl-2-sulfanylidene-1H-3,1-benzoxazin-6-yl)-1-methylpyrrole-2-carbonitrile

INCHI：InChI=1S/C16H15N3OS/c1-16(2)12-8-10(4-6-13(12)18-15(21)20-16)14-7-5-11(9-17)19(14)3/h4-8H,1-3H3,(H,18,21)

InChi Key：PYVFWTPEBMRKSR-UHFFFAOYSA-N

Canonical SMILES：CC1(C2=C(C=CC(=C2)C3=CC=C(N3C)C#N)NC(=S)O1)C

Isomeric SMILES：CC1(C2=C(C=CC(=C2)C3=CC=C(N3C)C#N)NC(=S)O1)C

PubChem CID：4369524

CAS Registry No.：304853-42-7

ChEMBL Ligand：CHEMBL539163

DrugBank Ligand：DB04787

Wikipedia：Tanaproget

RCSB PDB Ligand：T98

溶解性：25°C DMSO

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH373 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn child

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P260,P271,P304+P340,P403+P233,P362+P364,P203,P264+P265,P318,P337+P317,P332+P317,P319

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