产品名称

英文名称：CP-547632 hydrochloride

同义词

CP-547632 hydrochloride、252003-71-7、CP-547632 (hydrochloride)、UNII-OKR4BWW90F、OKR4BWW90F、3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-(4-pyrrolidin-1-ylbutylcarbamoylamino)-1,2-thiazole-4-carboxamide;hydrochloride、3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-

产品性质

CAS编号：252003-71-7

分子式：C20H25BrClF2N5O3S

分子量：568.86

PubChem编号：10370762

英文别名：CP-547632 hydrochloride|252003-71-7|CP-547632 (hydrochloride)|UNII-OKR4BWW90F|OKR4BWW90F|3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-(4-pyrrolidin-1-ylbutylcarbamoylamino)-1,2-thiazole-4-carboxamide;hydrochloride|3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-

规格或纯度：98% (HPLC)

英文名称：CP-547632 hydrochloride

生化机理：CP-547632 is a potent inhibitor of the VEGFR-2 and basic fibroblast growth factor (FGF) kinases (IC50 = 11 and 9 nM, respectively). The compound CP-547632 inhibits VEGF and basic FGF-induced angiogenesis in animal models, and inhibits growth of xenograft tumors in mice. CP-547632 hydrochloride is a well-tolerated, orally-bioavailable ATP-competitive kinase inhibitor. It is currently in clinical trials for the treatment of human malignancies.

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

产品介绍：产品介绍CP-547632 hydrochloride 是一种口服有效的，ATP 竞争性的 VEGFR-2 和 FGF 激酶抑制剂，IC50 分别为 11 nM 和 9 nM。CP-547632 hydrochloride 对 VEGFR2 和 bFGF 的选择性高于 EGFR，PDGFRβ 和相关的酪氨酸激酶 (TKs)。CP-547632 hydrochloride 具有抗肿瘤作用。

IUPAC Name：3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-(4-pyrrolidin-1-ylbutylcarbamoylamino)-1,2-thiazole-4-carboxamide;hydrochloride

INCHI：InChI=1S/C20H24BrF2N5O3S.ClH/c21-12-9-14(22)13(15(23)10-12)11-31-18-16(17(24)29)19(32-27-18)26-20(30)25-5-1-2-6-28-7-3-4-8-28;/h9-10H,1-8,11H2,(H2,24,29)(H2,25,26,30);1H

InChi Key：NNPJZJJMQDXYGN-UHFFFAOYSA-N

Canonical SMILES：C1CCN(C1)CCCCNC(=O)NC2=C(C(=NS2)OCC3=C(C=C(C=C3F)Br)F)C(=O)N.Cl

Isomeric SMILES：C1CCN(C1)CCCCNC(=O)NC2=C(C(=NS2)OCC3=C(C=C(C=C3F)Br)F)C(=O)N.Cl

PubChem CID：10370762

产品包装