产品名称

英文名称：Tetrabenazine

同义词

TETRABENAZINE、58-46-8、718635-93-9、Nitoman、Rubigen、Tetrabenzaine、Tetrabenzine、Tetrabenazine Racemate、Tetrabenazinum、tetra Benazin、Xenazine、Tetrabenazine (Racemate)、Tetrabenazinum [INN-Latin]、3-isobutyl-9,10-dimethoxy-3,4,6,7-tetrahydro-1H-pyrido[2,1-a]isoq、3-异丁基-9,10-二甲氧基-1,3,4,6,7,11b-六氢-2H-苯并[a]喹啉-2-酮

产品性质

CAS编号：58-46-8

分子式：C19H27NO3

分子量：317.42

Beilstein号：40090

EC号：200-383-6

MDL号：MFCD08461052

PubChem编号：6018

别名：3-异丁基-9,10-二甲氧基-1,3,4,6,7,11b-六氢-2H-苯并[a]喹啉-2-酮

英文别名：TETRABENAZINE|58-46-8|718635-93-9|Nitoman|Rubigen|Tetrabenzaine|Tetrabenzine|Tetrabenazine Racemate|Tetrabenazinum|tetra Benazin|Xenazine|Tetrabenazine (Racemate)|Tetrabenazinum [INN-Latin]|3-isobutyl-9,10-dimethoxy-3,4,6,7-tetrahydro-1H-pyrido[2,1-a]isoq

规格或纯度：98%

英文名称：Tetrabenazine

生化机理：Tetrabenazine is a reversible type 2 vesicular monoamine transporter (VMAT) inhibitor. It depletes dopamine stores.Potent, reversible VMAT2 inhibitor (IC 50 = 3.2 nM, K i = 100 nM). Depletes monoamines stores and decreases uptake into synaptic vesicles. Shows antihyperkinetic effects in vivo. Orally active.

应用：Usually used for dopamine uptake assays in mouse brain cells,and also has been used for non-specific binding assays in postnuclear supernatants derived from PC-12 and CV-1 cells.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Usually used for dopamine uptake assays in mouse brain cells,and also has been used for non-specific binding assays in postnuclear supernatants derived from PC-12 and CV-1 cells.Usually used for dopamine uptake assays in mouse brain cells,and also has been used for non-specific binding assays in postnuclear supernatants derived from PC-12 and CV-1 cells.

ALogP：2.9

IUPAC Name：9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydrobenzo[a]quinolizin-2-one

INCHI：InChI=1S/C19H27NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16H,5-7,10-11H2,1-4H3

InChi Key：MKJIEFSOBYUXJB-UHFFFAOYSA-N

Canonical SMILES：CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1=O)OC)OC

Isomeric SMILES：CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1=O)OC)OC

WGK Germany：3

RTECS：DK2275000

PubChem CID：6018

DrugBank Ligand：DB04844

CAS Registry No.：58-46-8

Wikipedia：Tetrabenazine

ChEMBL Ligand：CHEMBL117785

敏感性：对空气敏感，对热敏感

熔点：127 °C

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

Merck Index：9182

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

产品包装