产品名称

英文名称：20-HETE

同义词

20-Hete、79551-86-3、20-Hydroxyeicosatetraenoic acid、20-Hydroxy arachidonic acid、20-Hydroxyarachidonic acid、(5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoic acid、20-hydroxy-5,8,11,14-eicosatetraenoic acid、20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid

产品性质

CAS编号：79551-86-3

分子式：C20H32O3

分子量：320.47

MDL号：MFCD00171542

PubChem编号：5283157

英文别名：20-Hete|79551-86-3|20-Hydroxyeicosatetraenoic acid|20-Hydroxy arachidonic acid|20-Hydroxyarachidonic acid|(5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoic acid|20-hydroxy-5,8,11,14-eicosatetraenoic acid|20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid

规格或纯度：≥98%,a solution in ethanol

英文名称：20-HETE

生化机理：DescriptionIC50 Value N/A20-Hydroxyeicosatetraenoic acid (20-HETE) is a cytochrome P450-derived arachidonic acid metabolite that has been shown to increase smooth muscle contractions and proliferation, stimulate endothelial dysfunction and activation and promote hypertension.in vitro Addition of 20-HETE to the bath (1-100 nM), reduced the frequency of opening of the large-conductance Ca(2+)-activated K+ channel recorded using cell-attached patches on VSM [1]. In kidney, 20-HETE induces diuresis by inhibiting Na+-K+-ATPase in proximal tubules and Na+/K+/Cl+ cotransporter in the thick ascending limb of Henle's loop [2].in vivo In Cyp4a14(-/-) mice, which display androgen-driven and 20-HETE-dependent hypertension, treatment with20-HETE antagonist abolished remodeling of renal resistance arteries measured as media thickness (24±1 vs. 15±1μm) and M/L (0.29±0.03 vs. 0.17±0.01) [4]. The transgenic mice

储存温度：避光,-20°C储存

运输条件：超低温冰袋运输

产品介绍：20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid 20-HETE is supplied as a solution in ethanol. To change the solvent, simply evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice. Solvents such as ethanol, DMSO, and dimethyl formamide purged with an inert gas can be used. 20-HETE is miscible in these solvents.

IUPAC Name：(5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid

INCHI：InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10-

InChi Key：NNDIXBJHNLFJJP-DTLRTWKJSA-N

Canonical SMILES：C(CCC=CCC=CCC=CCC=CCCCC(=O)O)CCO

Isomeric SMILES：C(CC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O)CCO

WGK Germany：1

PubChem CID：5283157

ChEBI：CHEBI34306

CAS Registry No.：79551-86-3

溶解性：25°C DMSO

敏感性：对空气敏感；对光线敏感

闪点(℉)：57.2 °F

闪点(℃)：14 °C

信号词：Danger

危险声明：H319 Causes serious eye irritationH225 Highly Flammable liquid and vapor

预防措施声明：P305+P351+P338,P370+P378,P210,P403+P235

个人防护装备：Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

产品包装