产品名称

英文名称：Asenapine

同义词

CHEBI71253、AB01274757_02、(S,S)-asenapine、ASENAPINE [INN]、DTXCID3028974、rac-(3aR,12bR)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo(2,36,7)oxepino(4,5-c)pyrrole、(3aR,12bR)-rel-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz、1H-Dibenz(2,36,7)oxep、阿塞那平

产品性质

CAS编号：65576-45-6

分子式：C17H16ClNO

分子量：285.77

PubChem编号：163091

别名：阿塞那平

英文别名：CHEBI71253|AB01274757_02|(S,S)-asenapine|ASENAPINE [INN]|DTXCID3028974|rac-(3aR,12bR)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo(2,36,7)oxepino(4,5-c)pyrrole|(3aR,12bR)-rel-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz|1H-Dibenz(2,36,7)oxep

规格或纯度：≥96%

英文名称：Asenapine

生化机理：Asenapine is a new atypical antipsychotic developed for the treatment of schizophrenia and acute mania associated with bipolar disorder. Asenapine shows high affinity (pKi) for numerous receptors, including the serotonin 5-HT1A (8.6), 5-HT1B (8.4), 5-HT2A (10.2), 5-HT2B (9.8), 5-HT2C (10.5), 5-HT5A (8.8), 5-HT6 (9.5), and 5-HT7 (9.9) receptors, the adrenergic α1 (8.9), α2A (8.9), α2B (9.5), and α2C (8.9) receptors, the dopamine D1 (8.9), D2 (8.9), D3 (9.4), and D4 (9.0) receptors, and the histamine H1 (9.0) and H2 (8.2) receptors. Asenapine behaves as an antagonist at all receptors.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Asenapine(Org 5222)能抑制肾上腺素受体，对α1，α2A，α2B和α2C的Ki为0.25-1.2 nM，还能抑制 5-HT受体，对1A，1B，2A，2B，2C，5A，6和7的Ki为0.03-4.0 nM。Asenapine(Org 5222) inhibits adrenergic receptor (α1, α2A, α2B, α2C) with Ki of 0.25-1.2 nM and also inhibits 5-HT receptor (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with Ki of 0.03-4.0 nM.

IUPAC Name：(2S,6S)-9-chloro-4-methyl-13-oxa-4-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),7(12),8,10,14,16-hexaene

INCHI：InChI=1S/C17H16ClNO/c1-19-9-14-12-4-2-3-5-16(12)20-17-7-6-11(18)8-13(17)15(14)10-19/h2-8,14-15H,9-10H2,1H3/t14-,15-/m1/s1

InChi Key：VSWBSWWIRNCQIJ-HUUCEWRRSA-N

Canonical SMILES：CN1CC2C(C1)C3=C(C=CC(=C3)Cl)OC4=CC=CC=C24

Isomeric SMILES：CN1C[C@H]2[C@H](C1)C3=C(C=CC(=C3)Cl)OC4=CC=CC=C24

PubChem CID：163091

ChEBI：CHEBI71257

Wikipedia：Asenapine

CAS Registry No.：65576-45-6

ChEMBL Ligand：CHEMBL504548

PEP：asenapine

GPCRdb Ligand：asenapine

溶解性：DMSO 50 mg/mL (174.97 mM; Need ultrasonic) H2O < 0.1 mg/mL (insoluble)

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH301 Toxic if swallowedH331 Toxic if inhaledH400 Very toxic to aquatic lifeH410 Very toxic to aquatic life with long lasting effectsH372 Causes damage to organs through prolonged or repeated exposureH370 Causes damage to organsH361 Suspected of damaging fertility or the unborn child

预防措施声明：P261,P305+P351+P338,P273,P280,P302+P352,P321,P405,P501,P264,P260,P271,P270,P304+P340,P403+P233,P362+P364,P391,P330,P203,P264+P265,P301+P316,P318,P337+P317,P308+P316,P332+P317,P316,P319

产品包装