产品名称

英文名称：GW3965 HCl

同义词

405911-17-3、GW3965 hydrochloride、GW3965 HCl、2-(3-(3-((2-Chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)amino)propoxy)phenyl)acetic acid hydrochloride、GW 3965 HYDROCHLORIDE、GW3965 (hydrochloride)、GW-3965 hydrochloride、MFCD08276920、2-[3-[3-[[2-Chloro-3

产品性质

CAS编号：405911-17-3

分子式：C33H31ClF3NO3.HCl

分子量：618.51

MDL号：MFCD08276920

PubChem编号：16078973

英文别名：405911-17-3|GW3965 hydrochloride|GW3965 HCl|2-(3-(3-((2-Chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)amino)propoxy)phenyl)acetic acid hydrochloride|GW 3965 HYDROCHLORIDE|GW3965 (hydrochloride)|GW-3965 hydrochloride|MFCD08276920|2-[3-[3-[[2-Chloro-3

规格或纯度：≥97%

英文名称：GW3965 HCl

生化机理：GW3965 is a liver X receptor full agonist on hLXRα and hLXRβ. GW3965 has an EC50 = 125 nM in a cell-free ligand-sensing assay of LXRα and profiles as a full agonist on hLXRα and hLXRβ in cell-based assays with EC50 = 190 nM and 30 nM, respectively. It is orally active in mice. When screened against a panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR). The literature agonist, T0901317 (Tularik), had an EC50 = 60 nM and 85 nM in the cell-free and cell-based assays, respectively.Potent and selective LXR agonist (EC 50 values are 190 and 30 nM at hLXRα and hLXRβ, respectively). Reduces Ang II-mediated vasopressor responses in rats. Orally active. Anti-inflammatory, Hypolipidemic and antitumor agent. Active in vivo and in vitro .

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：GW3965 hydrochlorideGW3965 hydrochloride

IUPAC Name：2-[3-[3-[[2-chloro-3-(trifluoromethyl)phenyl]methyl-(2,2-diphenylethyl)amino]propoxy]phenyl]acetic acid;hydrochloride

INCHI：InChI=1S/C33H31ClF3NO3.ClH/c34-32-27(15-8-17-30(32)33(35,36)37)22-38(18-9-19-41-28-16-7-10-24(20-28)21-31(39)40)23-29(25-11-3-1-4-12-25)26-13-5-2-6-14-26;/h1-8,10-17,20,29H,9,18-19,21-23H2,(H,39,40);1H

InChi Key：NMPUWJFHNOUNQU-UHFFFAOYSA-N

Canonical SMILES：C1=CC=C(C=C1)C(CN(CCCOC2=CC=CC(=C2)CC(=O)O)CC3=C(C(=CC=C3)C(F)(F)F)Cl)C4=CC=CC=C4.Cl

Isomeric SMILES：C1=CC=C(C=C1)C(CN(CCCOC2=CC=CC(=C2)CC(=O)O)CC3=C(C(=CC=C3)C(F)(F)F)Cl)C4=CC=CC=C4.Cl

WGK Germany：3

关联CAS：405911-09-3（free）；405911-09-3（free basis）

PubChem CID：16078973

溶解性：DMSO 124 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

象形图：

信号词：Danger

危险声明：H413 May cause long lasting harmful effects to aquatic lifeH302 Harmful if swallowedH318 Causes serious eye damage

预防措施声明：P273,P280,P501,P264,P270,P330,P264+P265,P301+P317,P305+P354+P338,P317

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

产品包装