产品名称

英文名称：Pafuramidine

同义词

H1VG379J2X 、 4,4'-(Furan-2,5-diyl)bis(N-methoxybenzimidamide) 、 N'-methoxy-4-[5-[4-[(Z)-N'-methoxycarbamimidoyl]phenyl]furan-2-yl]benzenecarboximidamide 、 DB289

产品性质

CAS编号：186953-56-0

分子式：C20H20N4O3

分子量：364.40

PubChem编号：5480200

英文别名：H1VG379J2X | 4,4'-(Furan-2,5-diyl)bis(N-methoxybenzimidamide) | N'-methoxy-4-[5-[4-[(Z)-N'-methoxycarbamimidoyl]phenyl]furan-2-yl]benzenecarboximidamide | DB289

规格或纯度：≥98%

英文名称：Pafuramidine

生化机理：DescriptionIC50 Value 4.5 nM(In vitro inhibitory activity against Trypanosoma brucei rhodesiense) [4]DB289 (pafuramidine maleate; 2,5-bis[4-(N-methoxyamidino)phenyl]furan monomaleate) is a prodrμg of DB75 (furamidine dihydrochloride; 2,5-bis(4-guanylphenyl)furan dihydrochloride), an aromatic dication related to pentamidine that has demonstrated good efficacy against African trypanosomiasis, Pneumocystis carinii pneumonia, and malaria, but lacks adequate oral availability.in vitro The results of this investigation sμggest that DB75 inhibits mitochondrial function. Yeast cells relying upon mitochondrial metabolism for energy production are especially sensitive to DB75 [1].in vivo Clearance of DB289 approximated the liver plasma flow and its large volume of distribution was consistent with extensive tissue binding. Plasma protein binding of DB289 was 97 to 99% in four animal species and humans, but that of DB75 was noticeably less and mor

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Pafuramidine (DB289) 是一种具有口服活性的 Furamidine 前体。Pafuramidine 是一种有效的抗寄生虫剂，可用于锥虫病、肺囊虫肺炎和疟疾的研究。 Pafuramidine (DB289) is an orally active proagent of Furamidine. Pafuramidine is a potent anti-parasitic agent, can be used to research trypanosomiasis, Pneumocystis pneumonia and malaria.

IUPAC Name：N'-methoxy-4-[5-[4-[(Z)-N'-methoxycarbamimidoyl]phenyl]furan-2-yl]benzenecarboximidamide

INCHI：InChI=1S/C20H20N4O3/c1-25-23-19(21)15-7-3-13(4-8-15)17-11-12-18(27-17)14-5-9-16(10-6-14)20(22)24-26-2/h3-12H,1-2H3,(H2,21,23)(H2,22,24)

InChi Key：UKOQVLAXCBRRGH-UHFFFAOYSA-N

Canonical SMILES：CON=C(C1=CC=C(C=C1)C2=CC=C(O2)C3=CC=C(C=C3)C(=NOC)N)N

Isomeric SMILES：CO/N=C(\N)/C1=CC=C(C=C1)C2=CC=C(O2)C3=CC=C(C=C3)/C(=N/OC)/N

PubChem CID：5480200

CAS Registry No.：186953-56-0

ChEMBL Ligand：CHEMBL319669

DrugBank Ligand：DB06532

Antibiotic DB：464

溶解性：25°C DMSO

产品包装