产品名称

英文名称：Lersivirine

同义词

Lersivirine、473921-12-9、UK-453061、3-CYANO-5-[[3,5-DIETHYL-1-(2-HYDROXYETHYL)-1H-PYRAZOL-4-YL]OXY]BENZONITRILE、UK-453,061、LersivirineUK 453061、R3ZGC15A9A、5-((3,5-diethyl-1-(2-hydroxyethyl)-1H-pyrazol-4-yl)oxy)isophthalonitrile、5-[3,5-diethyl-1-(2-hydroxyet

产品性质

CAS编号：473921-12-9

分子式：C17H18N4O2

分子量：310.35

PubChem编号：16739244

英文别名：Lersivirine|473921-12-9|UK-453061|3-CYANO-5-[[3,5-DIETHYL-1-(2-HYDROXYETHYL)-1H-PYRAZOL-4-YL]OXY]BENZONITRILE|UK-453,061|LersivirineUK 453061|R3ZGC15A9A|5-((3,5-diethyl-1-(2-hydroxyethyl)-1H-pyrazol-4-yl)oxy)isophthalonitrile|5-[3,5-diethyl-1-(2-hydroxyet

英文名称：Lersivirine

生化机理：Lersivirine (UK-453061) is a next-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) under development for the treatment of HIV-1 infection. Lersivirine prevents HIV from entering the nucleus of healthy CD4 cells. This prevents the cells from producing new virus and decreases the amount of virus in the body. Lersivirine, a weak inducer of the cytochrome P450 (CYP) enzyme CYP3A4, is metabolized by CYP3A4 and UDP glucuronosyltransferase 2B7 (μgT2B7).

储存温度：-20°C储存

运输条件：超低温冰袋运输

ALogP：2.1

IUPAC Name：5-[3,5-diethyl-1-(2-hydroxyethyl)pyrazol-4-yl]oxybenzene-1,3-dicarbonitrile

INCHI：InChI=1S/C17H18N4O2/c1-3-15-17(16(4-2)21(20-15)5-6-22)23-14-8-12(10-18)7-13(9-14)11-19/h7-9,22H,3-6H2,1-2H3

InChi Key：MCPUZZJBAHRIPO-UHFFFAOYSA-N

Canonical SMILES：CCC1=C(C(=NN1CCO)CC)OC2=CC(=CC(=C2)C#N)C#N

Isomeric SMILES：CCC1=C(C(=NN1CCO)CC)OC2=CC(=CC(=C2)C#N)C#N

PubChem CID：16739244

溶解性：DMSO

象形图：

信号词：Warning

危险声明：H373 Causes damage to organs through prolonged or repeated exposureH412 Harmful to aquatic life with long lasting effectsH361 Suspected of damaging fertility or the unborn child

预防措施声明：P273,P280,P405,P501,P260,P203,P318,P319

产品包装