产品名称

英文名称：PRX-08066

同义词

PRX-08066、866206-54-4、PRX-08066 free base、PRX 08066、5-((4-(6-Chlorothieno(2,3-d)pyrimidine-4-ylamino)piperidin-1-yl)methyl)-2-fluorobenzonitrile、82SK298EBU、CHEMBL513994、5-((4-((6-chlorothieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-2-fluorobenzo

产品性质

CAS编号：866206-54-4

分子式：C19H17ClFN5S

分子量：401.89

PubChem编号：11502243

英文别名：PRX-08066|866206-54-4|PRX-08066 free base|PRX 08066|5-((4-(6-Chlorothieno(2,3-d)pyrimidine-4-ylamino)piperidin-1-yl)methyl)-2-fluorobenzonitrile|82SK298EBU|CHEMBL513994|5-((4-((6-chlorothieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-2-fluorobenzo

英文名称：PRX-08066

生化机理：PRX-08066 is a selective 5-hydroxytryptamine receptor 2B (5-HT2BR) antagonist that causes selective vasodilation of pulmonary arteries. PRX-08066 significantly reduced peak PA pressure at 50 and 100 mg/kg (P < 0.05 and < 0.01, respectively) compared with MCT control animals. The 5-HT2BR antagonist PRX-08066 significantly attenuated the elevation in PA pressure and RV hypertrophy and maintained cardiac function. PRX-08066 prevents the severity of PAH in the MCT rat model.

储存温度：-20°C储存

运输条件：超低温冰袋运输

IUPAC Name：5-[[4-[(6-chlorothieno[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]methyl]-2-fluorobenzonitrile

INCHI：InChI=1S/C19H17ClFN5S/c20-17-8-15-18(23-11-24-19(15)27-17)25-14-3-5-26(6-4-14)10-12-1-2-16(21)13(7-12)9-22/h1-2,7-8,11,14H,3-6,10H2,(H,23,24,25)

InChi Key：IENZFHBNCRQMNP-UHFFFAOYSA-N

Canonical SMILES：C1CN(CCC1NC2=C3C=C(SC3=NC=N2)Cl)CC4=CC(=C(C=C4)F)C#N

Isomeric SMILES：C1CN(CCC1NC2=C3C=C(SC3=NC=N2)Cl)CC4=CC(=C(C=C4)F)C#N

PubChem CID：11502243

溶解性：DMSO

产品包装