产品名称

英文名称：QL-IX-55

同义词

QL-IX-55、1223002-54-7、9-(6-aminopyridin-3-yl)-1-(4-fluoro-3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one、CHEMBL1765605、9-(6-aminopyridin-3-yl)-1-[4-fluoro-3-(trifluoromethyl)phenyl]benzo[h][1,6]naphthyridin-2-one、9-(6-Amino-3-pyridinyl)-1-[

产品性质

CAS编号：1223002-54-7

分子式：C24H14F4N4O

分子量：450.39

PubChem编号：51350805

英文别名：QL-IX-55|1223002-54-7|9-(6-aminopyridin-3-yl)-1-(4-fluoro-3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one|CHEMBL1765605|9-(6-aminopyridin-3-yl)-1-[4-fluoro-3-(trifluoromethyl)phenyl]benzo[h][1,6]naphthyridin-2-one|9-(6-Amino-3-pyridinyl)-1-[

英文名称：QL-IX-55

生化机理：The functional target of QL-IX-55 is the ATP-binding site of TOR2 as evidenced by the discovery of resistant alleles of TOR2 throμgh rational design and unbiased selection strategies. QL-IX-55 is capable of potently inhibiting both TOR complex 1 and 2 (TORC1 and TORC2) as demonstrated by biochem. IP kinase assays (IC50 <50 nM) and cellular assays for inhibition of substrate YPK1 phosphorylation. In contrast to rapamycin, QL-IX-55 is capable of inhibiting TORC2-dependent transcription, which sμggests that this compd. will be a powerful probe to dissect the Tor2/TORC2-related signaling pathway in yeast.

储存温度：-20°C储存

运输条件：超低温冰袋运输

IUPAC Name：9-(6-aminopyridin-3-yl)-1-[4-fluoro-3-(trifluoromethyl)phenyl]benzo[h][1,6]naphthyridin-2-one

INCHI：InChI=1S/C24H14F4N4O/c25-19-5-4-16(10-18(19)24(26,27)28)32-22(33)8-3-15-12-30-20-6-1-13(9-17(20)23(15)32)14-2-7-21(29)31-11-14/h1-12H,(H2,29,31)

InChi Key：MXRMEHBVJBSIPI-UHFFFAOYSA-N

Canonical SMILES：C1=CC2=NC=C3C=CC(=O)N(C3=C2C=C1C4=CN=C(C=C4)N)C5=CC(=C(C=C5)F)C(F)(F)F

Isomeric SMILES：C1=CC2=NC=C3C=CC(=O)N(C3=C2C=C1C4=CN=C(C=C4)N)C5=CC(=C(C=C5)F)C(F)(F)F

PubChem CID：51350805

溶解性：DMSO

产品包装