产品名称

英文名称：MK-6892

同义词

MK-6892、917910-45-3、PH9ZB6IRW0、MK 6892、CHEMBL1086657、1-Cyclohexene-1-carboxylic acid, 2-((3-(3-(5-hydroxy-2-pyridinyl)-1,2,4-oxadiazol-5-yl)-2,2-dimethyl-1-oxopropyl)amino)-、2-[[3-[3-(5-Hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-yl]-2,2-dimethylpropanoyl]amin

产品性质

CAS编号：917910-45-3

分子式：C19H22N4O5

分子量：386.4

PubChem编号：135416394

英文别名：MK-6892|917910-45-3|PH9ZB6IRW0|MK 6892|CHEMBL1086657|1-Cyclohexene-1-carboxylic acid, 2-((3-(3-(5-hydroxy-2-pyridinyl)-1,2,4-oxadiazol-5-yl)-2,2-dimethyl-1-oxopropyl)amino)-|2-[[3-[3-(5-Hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-yl]-2,2-dimethylpropanoyl]amin

规格或纯度：98%

英文名称：MK-6892

生化机理：DescriptionIC50 Value 4.0 nM (Ki for Human GPR109A) [1]MK-6892 is a highly potential GPR109A agonists.in vitro . Despite the increased serum shift of these compounds, the representative 1e was highly potent. Furthermore, these compounds had no activity on GPR109B and GPR81, the two most closely related GPCRs with ?96% and 50% sequence identity to GPR109A,respectively [1].in vivo NA or MK-6892 was orally administered to WT or NA receptor mice on the same C57Bl/6 genetic background. After 15 min of 100 mpk dosing of NA or MK-6892 to fed WT or NA receptor mice, the blood levels of MK-6892 at 15 min were 229 μM (?950-fold greater than the in vitro EC50 determined in mouse NA receptor GTPγS assay, which is 240 nM) in WT mice and 148 μM (?620-fold greater than the in vitro EC50) in NA receptor mice [1].Clinical trial N/A

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：applicationDescription IC50 Value 4.0 nM (Ki for Human GPR109A) MK-6892 is a highly potential GPR109A agonists. in vitro . Despite the increased serum shift of these compounds, the representative 1e was highly potent. Furthermore, these compounds had no activity on GPR109B and GPR81, the two most closely related GPCRs with ?96% and 50% sequence identity to GPR109A,respectively . in vivo NA or MK-6892 was orally administered to WT or NA receptor mice on the same C57Bl/6 genetic background. After 15 min of 100 mpk dosing of NA or MK-6892 to fed WT or NA receptor mice, the blood levels of MK-6892 at 15 min were 229 μM (?950-fold greater than the in vitro EC50 determined in mouse NA receptor GTPγS assay, which is 240 nM) in WT mice and 148 μM (?620-fold greater than the in vitro EC50) in NA receptor mice . Clinical trial N/A

IUPAC Name：2-[[3-[3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-yl]-2,2-dimethylpropanoyl]amino]cyclohexene-1-carboxylic acid

INCHI：InChI=1S/C19H22N4O5/c1-19(2,18(27)21-13-6-4-3-5-12(13)17(25)26)9-15-22-16(23-28-15)14-8-7-11(24)10-20-14/h7-8,10,24H,3-6,9H2,1-2H3,(H,21,27)(H,25,26)

InChi Key：CJHXBFSJXDUJHP-UHFFFAOYSA-N

Canonical SMILES：CC(C)(CC1=NC(=NO1)C2=NC=C(C=C2)O)C(=O)NC3=C(CCCC3)C(=O)O

Isomeric SMILES：CC(C)(CC1=NC(=NO1)C2=NC=C(C=C2)O)C(=O)NC3=C(CCCC3)C(=O)O

PubChem CID：135416394

CAS Registry No.：917910-45-3

ChEMBL Ligand：CHEMBL1086657

GPCRdb Ligand：MK 6892

RCSB PDB Ligand：FI7

溶解性：25°C DMSO

产品包装