产品名称

英文名称：RO-9187

同义词

RO-9187、876708-03-1、RO 9187、4-Amino-1-[(2r,3s,4s,5r)-5-azido-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one、CHEMBL513181、SCHEMBL13471886、DTXSID30467889、BKB70803、EX-A6754、AKOS040742565、CS-0954、NCGC00378981-01、NCGC00378981-02、CID 11514721、HY-108

产品性质

CAS编号：876708-03-1

分子式：C9H12N6O5

分子量：284.23

PubChem编号：11514721

英文别名：RO-9187|876708-03-1|RO 9187|4-Amino-1-[(2r,3s,4s,5r)-5-azido-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one|CHEMBL513181|SCHEMBL13471886|DTXSID30467889|BKB70803|EX-A6754|AKOS040742565|CS-0954|NCGC00378981-01|NCGC00378981-02|CID 11514721|HY-108

规格或纯度：≥99%

英文名称：RO-9187

生化机理：RO-9187 is a potent inhibitor of HCV virus replication in the replicon system (IC(50) = 171 +/- 12 nM; CC(50) >1 mM). Pharmacokinetic studies with RO-9187 in rats and dogs showed that plasma concentrations exceeding HCV replicon IC(50) values 8-150-fold could be achieved by low dose (10 mg/kg) oral administration.

储存温度：-20°C储存

运输条件：超低温冰袋运输

IUPAC Name：4-amino-1-[(2R,3S,4S,5R)-5-azido-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

INCHI：InChI=1S/C9H12N6O5/c10-4-1-2-15(8(19)12-4)7-5(17)6(18)9(3-16,20-7)13-14-11/h1-2,5-7,16-18H,3H2,(H2,10,12,19)/t5-,6-,7+,9+/m0/s1

InChi Key：ODLGMSQBFONGNG-XZMZPDFPSA-N

Canonical SMILES：C1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)N=[N+]=[N-])O)O

Isomeric SMILES：C1=CN(C(=O)N=C1N)[C@H]2[C@H]([C@@H]([C@](O2)(CO)N=[N+]=[N-])O)O

PubChem CID：11514721

溶解性：DMSO

产品包装