产品名称

英文名称：SMIP004

同义词

143360-00-3、SMIP004、N-(4-butyl-2-methylphenyl)acetamide、N1-(4-butyl-2-methylphenyl)acetamide、Acetamide,N-(4-butyl-2-methylphenyl)-、Maybridge1_000068、MixCom1_000134、SCHEMBL4393968、DTXSID40372672、MFCD00277686、AKOS015908670、4'-(But-1-yl)-2'-methylacetanilide

产品性质

CAS编号：143360-00-3

分子式：C13H19NO

分子量：205.3

PubChem编号：2747581

英文别名：143360-00-3|SMIP004|N-(4-butyl-2-methylphenyl)acetamide|N1-(4-butyl-2-methylphenyl)acetamide|Acetamide,N-(4-butyl-2-methylphenyl)-|Maybridge1_000068|MixCom1_000134|SCHEMBL4393968|DTXSID40372672|MFCD00277686|AKOS015908670|4'-(But-1-yl)-2'-methylacetanilide

规格或纯度：≥98%

英文名称：SMIP004

生化机理：DescriptionIC50 Value 1.09 uM (MTT assay in LNCaP-S14 cells) [1]SMIP004 (N-(4-butyl-2-methyl-phenyl) acetamide) is a novel inducer of cancer-cell selective apoptosis of human prostate cancer cells. Unlike SMIP001, SMIP004 was found to downregulate SKP2 and to stabilize p27, althoμgh neither SMIP is a proteasome inhibitor.in vitro Whereas SMIP012 and 016 were moderately toxic in normal fibroblasts, SMIPs 001 and 004 showed substantial cancer cell specificity being at least five times more potent in LNCaP-S14 than in IMR90 cells , treatment with either MG132 or SMIP004 increased p27 half-life to > 6 h [1]. Both SMIP001 and 004 led to a strong increase in the recruitment of p27 to CDK2, while SMIP001 also slightly increased coprecipitation of p21 (Figure 6c). SMIP004 also reduced the amounts of cyclins E and A retrieved with CDK2. This was paralleled by a marked downregulation of cyclins E and A upon SMIP004 treatment. SMIP004 decreased the levels of positive cell cycle regulators, upregulated cyclin-dependent kinase inhibitors, and resulted in G1 arrest, inhibition of colony formation in soft agar, and cell death [2].in vivo SMIP004 potently inhibits the growth of prostate and breast cancer xenografts in mice [2].Clinical trial N/A

储存温度：-20°C储存

运输条件：超低温冰袋运输

IUPAC Name：N-(4-butyl-2-methylphenyl)acetamide

INCHI：InChI=1S/C13H19NO/c1-4-5-6-12-7-8-13(10(2)9-12)14-11(3)15/h7-9H,4-6H2,1-3H3,(H,14,15)

InChi Key：ZFVMECVBUGMWIX-UHFFFAOYSA-N

Canonical SMILES：CCCCC1=CC(=C(C=C1)NC(=O)C)C

Isomeric SMILES：CCCCC1=CC(=C(C=C1)NC(=O)C)C

PubChem CID：2747581

溶解性：25°C DMSO

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH302 Harmful if swallowed

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P264+P265,P301+P317,P337+P317,P332+P317,P319

产品包装