产品名称

英文名称：HC-030031

同义词

HC-030031、349085-38-7、2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide、HC 030031、2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-N-(4-propan-2-ylphenyl)acetamide、MU78VFH9C7、HC030031、C18H21N5O3、UNII-MU78VFH9C7、CHEMBL1086310、2、HC 030031、HC030031、1,2,3,6-四氢-1,3-二甲基-N- [4-(1-甲基乙基)苯基]-2,6-二氧代-7H-嘌呤-7-乙酰胺、2-(1,3-二甲基-2,6-二氧代-1,2,3,6-四氢-7H-嘌呤-7-基)-N-(4-异丙基苯基)乙酰胺

产品性质

CAS编号：349085-38-7

分子式：C18H21N5O3

分子量：355.39

MDL号：MFCD02007349

PubChem编号：1150897

别名：HC 030031|HC030031|1,2,3,6-四氢-1,3-二甲基-N- [4-(1-甲基乙基)苯基]-2,6-二氧代-7H-嘌呤-7-乙酰胺|2-(1,3-二甲基-2,6-二氧代-1,2,3,6-四氢-7H-嘌呤-7-基)-N-(4-异丙基苯基)乙酰胺

英文别名：HC-030031|349085-38-7|2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide|HC 030031|2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-N-(4-propan-2-ylphenyl)acetamide|MU78VFH9C7|HC030031|C18H21N5O3|UNII-MU78VFH9C7|CHEMBL1086310|2

规格或纯度：≥98%

英文名称：HC-030031

生化机理：HC-030031 is a substituted theophylline derivative. Potent and selective ANKTM1 (TRPA1) inhibitor. It antagonizes allyl isothiocyanate (AITC)- and formalin-evoked calcium influx with IC50 values of 6.2 and 5.3 μM respectively. Both inward and outward currents elicited by AITC or formalin are rapidly and reversibly blocked by HC-030031 which also blocks the activation of TRPA1 by N-methylmaleimide and by electrophillic prostaglandins2. TRPV1, TRPV3, TRPV4, hERG and NaV1.2 are not blocked.Selective TRPA1 blocker, orally active. Blocks TRPA1-mediated currents (IC 50 = 0.7 μM) and selective over TRPV1, TRPV3, TRPV4, hERG, and Na V 1.2 channels (IC 50 >10 μM).

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：HC-030031是TRPA1通道阻断剂，能拮抗AITC和福尔马林诱发的钙流，IC50分别为6.2 μM和5.3 μM。 A potent and selective TRPA1 inhibitorHC-030031 is a selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively.A potent and selective TRPA1 inhibitor

IUPAC Name：2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-N-(4-propan-2-ylphenyl)acetamide

INCHI：InChI=1S/C18H21N5O3/c1-11(2)12-5-7-13(8-6-12)20-14(24)9-23-10-19-16-15(23)17(25)22(4)18(26)21(16)3/h5-8,10-11H,9H2,1-4H3,(H,20,24)

InChi Key：HEQDZPHDVAOBLN-UHFFFAOYSA-N

Canonical SMILES：CC(C)C1=CC=C(C=C1)NC(=O)CN2C=NC3=C2C(=O)N(C(=O)N3C)C

Isomeric SMILES：CC(C)C1=CC=C(C=C1)NC(=O)CN2C=NC3=C2C(=O)N(C(=O)N3C)C

WGK Germany：3

PubChem CID：1150897

CAS Registry No.：349085-38-7

ChEMBL Ligand：CHEMBL1086310

溶解性：DMSO 32 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

密度：1.33

折光率：1.65

沸点：650.65° C

熔点：221-223°C

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowed

预防措施声明：P321,P405,P501,P264,P270,P330,P301+P316

个人防护装备：Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

产品包装