产品名称

英文名称：Mifepristone

同义词

RU486 、 RU 38486 、 11β-[4-(Dimethylamino)phenyl]-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one、米非司酮 、 11β-[4-(N,N-二甲胺基)]苯基-17β-羟基-17α-(1-丙炔基)-雌甾-4,9-二烯-3-酮 、 (1Lβ,17β)-11-[4-(二甲氨基)苯基]-17-羟基-17-(1-丙炔基)雌甾-4,9-二烯-3-酮 、 美服培酮

产品性质

CAS编号：84371-65-3

分子式：C29H35NO2

分子量：429.59

PubChem编号：55245

别名：米非司酮 | 11β-[4-(N,N-二甲胺基)]苯基-17β-羟基-17α-(1-丙炔基)-雌甾-4,9-二烯-3-酮 | (1Lβ,17β)-11-[4-(二甲氨基)苯基]-17-羟基-17-(1-丙炔基)雌甾-4,9-二烯-3-酮 | 美服培酮

英文别名：RU486 | RU 38486 | 11β-[4-(Dimethylamino)phenyl]-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one

规格或纯度：≥98%

英文名称：Mifepristone

生化机理：Mifepristone is a progesterone (PR) and glucocorticoid receptor (GR) antagonist which has demonstrated the ability to suppress activation of NFκB, a nuclear transcription factor that affects the expression of various adhesion molecules and several inflammatory genes. It is also an inhibitor of the progesterone receptor. Mifepristone has been found to decrease basal bcl-2 messenger RNA levels in CA1 neural regions and the dentate gyrus. Experiments have shown that mifepristone potentially exhibits an inhibitory effect on embryo implantation via regulation of FAS and FAS-L apoptosis gene expression. Additionally, mifepristone displays anti-angiogenic characteristics via suppression of vascular endothelial growth factor (VEGF) production. Mifepristone may also prevent intracellular peroxide accumulation and cell death induced by hydrogen peroxide, glutamate, β-amyloid protein, or neurotoxins that have been associated with certain neurodegenerative disorders.A cell-permeable synthetic steroid that acts as a potent selective antagonist of progesterone (PR) and glucocorticoid (GR) receptors in vitro and in vivo . Acts as a silent antagonist at PR and has a higher affinity than progesterone.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Mifepristone是一种异常活跃的孕激素受体和糖皮质激素受体拮抗剂，IC50分别为0.2nM和2.6 nM。A progesterone and glucocorticoid antagonist, suppresses VEGF production.Mifepristone is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively.A progesterone and glucocorticoid antagonist, suppresses VEGF production.

ALogP：3.8

IUPAC Name：(8S,11R,13S,14S,17S)-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one

INCHI：InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1

InChi Key：VKHAHZOOUSRJNA-GCNJZUOMSA-N

Canonical SMILES：CC#CC1(CCC2C1(CC(C3=C4CCC(=O)C=C4CCC23)C5=CC=C(C=C5)N(C)C)C)O

Isomeric SMILES：CC#C[C@@]1(CC[C@@H]2[C@@]1(C[C@@H](C3=C4CCC(=O)C=C4CC[C@@H]23)C5=CC=C(C=C5)N(C)C)C)O

WGK Germany：3

RTECS：KG2955000

PubChem CID：55245

Reaxy-Rn：5779404

DrugBank Ligand：DB00834

BindingDB Ligand：18627

Wikipedia：Mifepristone

CAS Registry No.：84371-65-3

ChEMBL Ligand：CHEMBL1276308

ChEBI：CHEBI50692

NURSA Ligand：10.1621/ST5A19ZOKW

RCSB PDB Ligand：486

PEP：mifepristone

DrugCentral Ligand：1805

溶解性：Soluble in water (partly), DMF (~30 mg/ml), ethanol (50 mg/ml), methanol, and DMSO (86 mg/ml at 25 °C).(Soluble) chloroform

敏感性：对热敏感

比旋光度：141° (C=0.5,CHCl3)

熔点：195 °C

象形图：

信号词：Danger

危险声明：H302 Harmful if swallowedH312 Harmful in contact with skinH332 Harmful if inhaledH360 May damage fertility or the unborn childH362 May cause harm to breast-fed children

预防措施声明：P261,P280,P302+P352,P321,P405,P501,P264,P260,P271,P270,P304+P340,P362+P364,P330,P263,P203,P301+P317,P318,P317

Merck Index：6186

个人防护装备：Eyeshields， full-face particle respirator type N100 (US)， Gloves， respirator cartridge type N100 (US)， type P1 (EN143) respirator filter， type P3 (EN 143) respirator cartridges

产品包装