产品名称

英文名称：Olanzapine

同义词

olanzapine、132539-06-1、Zyprexa、Olansek、Zalasta、Zyprexa Zydis、Zyprexa Velotab、Zyprexa Intramuscular、Olanzapine Mylan、olanzapina、Zolafren、Zypadhera、Olazax、LY-170053、Olanzapine Teva、Olazax Disperzi、2-Methyl-4-(4-methylpiperazin-1-yl)-10H-benzo[b]thieno[2,3-e、奥氮平、2-甲基-4-(4-甲基-1-哌嗪基)-10H-噻吩并[2,3-b][1,5]苯二氮䓬

产品性质

CAS编号：132539-06-1

分子式：C17H20N4S

分子量：312.43

Beilstein号：7655141

MDL号：MFCD00866702

PubChem编号：135398745

别名：奥氮平|2-甲基-4-(4-甲基-1-哌嗪基)-10H-噻吩并[2,3-b][1,5]苯二氮䓬|

英文别名：olanzapine|132539-06-1|Zyprexa|Olansek|Zalasta|Zyprexa Zydis|Zyprexa Velotab|Zyprexa Intramuscular|Olanzapine Mylan|olanzapina|Zolafren|Zypadhera|Olazax|LY-170053|Olanzapine Teva|Olazax Disperzi|2-Methyl-4-(4-methylpiperazin-1-yl)-10H-benzo[b]thieno[2,3-e

规格或纯度：≥99%

英文名称：Olanzapine

生化机理：Olanzapine(Zyprexa) is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist. It has a higher affinity for 5-HT2 serotonin receptors than D2 dopamine receptors. Like most atypical antipsychotics, compared to the older typical ones, olanzapine has a lower affinity for histamine, cholinergic muscarinic and alpha adrenergic receptors. Olanzapine also exhibits weak affinity for GABAA, BZD receptor site which may contribute slightly to its sedating properties. Antagonizing H1 histamine receptors causes sedation and may cause weight gain, althoμgh antagonistic actions at 5-HT2C receptors have also been implicated in weight gain.5-HT and D 2 antagonist (K i values are 4 (5-HT 2A ), 11 (5-HT 2C ) and 57 (5-HT 3 ), 31 (D 1 ), 11 (D 2 ) and 27 nM (D 4 )).

储存温度：避光,-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Olanzapine是一种高亲和力的5-HT2 5-羟色胺和多巴胺D2受体拮抗剂。A D2DR and serotonin inhibitorOlanzapine is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist.Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Olanzapine is an atypical antipsychotic drug, widely used for the treatment of acute schizophrenia and psychotic conditions.A D2DR and serotonin inhibitor

ALogP：2.9

PubChem SID：488202827

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488202827

IUPAC Name：2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine

INCHI：InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3

InChi Key：KVWDHTXUZHCGIO-UHFFFAOYSA-N

Canonical SMILES：CC1=CC2=C(S1)NC3=CC=CC=C3N=C2N4CCN(CC4)C

Isomeric SMILES：CC1=CC2=C(S1)NC3=CC=CC=C3N=C2N4CCN(CC4)C

WGK Germany：3

RTECS：XJ9007750

PubChem CID：135398745

Reaxy-Rn：7655141

DrugBank Ligand：DB00334

CAS Registry No.：132539-06-1

Wikipedia：Olanzapine

BindingDB Ligand：50053711

PEP：olanzapine

GPCRdb Ligand：olanzapine

溶解性：DMSO 100 mg/ml 1eq. HCl 100 mg/ml;Soluble in Acetronitrile

敏感性：对热和光线敏感

熔点：192-196°C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH301 Toxic if swallowedH373 Causes damage to organs through prolonged or repeated exposureH317 May cause an allergic skin reactionH336 May cause drowsiness or dizziness

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P260,P271,P270,P304+P340,P403+P233,P272,P333+P313,P362+P364,P330,P264+P265,P301+P316,P337+P317,P332+P317,P319

Merck Index：6822

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