产品名称

英文名称：ZM323881

同义词

ZM323881、193001-14-8、5-((7-(benzyloxy)quinazolin-4-yl)amino)-4-fluoro-2-methylphenol、ZM 323881、ZM-323881、CHEMBL1558704、4-fluoro-2-methyl-5-[(7-phenylmethoxyquinazolin-4-yl)amino]phenol、5-{[7-(benzyloxy)quinazolin-4-yl]amino}-4-fluoro-2-methylphenol、ZM 323

产品性质

CAS编号：193001-14-8

分子式：C22H18FN3O2

分子量：375.4

PubChem编号：16759369

英文别名：ZM323881|193001-14-8|5-((7-(benzyloxy)quinazolin-4-yl)amino)-4-fluoro-2-methylphenol|ZM 323881|ZM-323881|CHEMBL1558704|4-fluoro-2-methyl-5-[(7-phenylmethoxyquinazolin-4-yl)amino]phenol|5-{[7-(benzyloxy)quinazolin-4-yl]amino}-4-fluoro-2-methylphenol|ZM 323

英文名称：ZM323881

生化机理：ZM323881 is a potent and selective inhibitor of human vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) activity. ZM323881 selectively inhibits VEGFR-2 (IC50 = 2 nM) over VEGFR-1 and a range of other receptor tyrosine kinases such as PDGFRβ, FGFR1, EGFR and erbB2 (IC50 > 50 μM). ZM323881 inhibits VEGF-A-induced endothelial cell proliferation in vitro (IC50 = 8 nM).

储存温度：-20°C储存

运输条件：超低温冰袋运输

IUPAC Name：4-fluoro-2-methyl-5-[(7-phenylmethoxyquinazolin-4-yl)amino]phenol

INCHI：InChI=1S/C22H18FN3O2/c1-14-9-18(23)20(11-21(14)27)26-22-17-8-7-16(10-19(17)24-13-25-22)28-12-15-5-3-2-4-6-15/h2-11,13,27H,12H2,1H3,(H,24,25,26)

InChi Key：NVBNDZZLJRYRPD-UHFFFAOYSA-N

Canonical SMILES：CC1=CC(=C(C=C1O)NC2=NC=NC3=C2C=CC(=C3)OCC4=CC=CC=C4)F

Isomeric SMILES：CC1=CC(=C(C=C1O)NC2=NC=NC3=C2C=CC(=C3)OCC4=CC=CC=C4)F

PubChem CID：16759369

溶解性：DMSO

产品包装