产品名称

英文名称：Procaine hydrochloride

同义词

PROCAINE HYDROCHLORIDE、51-05-8、Procaine Hcl、Naucaine、Neocaine、Omnicain、Planocaine、Anestil、Novocain、2-(diethylamino)ethyl 4-aminobenzoate hydrochloride、Atoxicocaine、Neotonocaine、Allocaine、Aminocaine、Anadolor、Anesthesol、Bernocaine、Chlorocaine、Ethocaine、Euge、普鲁卡因盐酸盐、4-氨基苯甲酸-2-二乙氨乙酯、奴佛卡因 盐酸盐、对氨基苯甲酸二乙氨乙酯 盐酸盐、2-(二乙氨基)乙基4-氨基苯甲酸酯盐酸盐、4-氨基苯甲酸-2-(二乙氨基)乙酯单盐酸盐

产品性质

CAS编号：51-05-8

分子式：C13H20N2O2·HCl

分子量：272.77

Beilstein号：3917802

EC号：200-077-2

MDL号：MFCD00013000

PubChem编号：5795

别名：普鲁卡因盐酸盐|4-氨基苯甲酸-2-二乙氨乙酯|奴佛卡因 盐酸盐|对氨基苯甲酸二乙氨乙酯 盐酸盐|2-(二乙氨基)乙基4-氨基苯甲酸酯盐酸盐|4-氨基苯甲酸-2-(二乙氨基)乙酯单盐酸盐

英文别名：PROCAINE HYDROCHLORIDE|51-05-8|Procaine Hcl|Naucaine|Neocaine|Omnicain|Planocaine|Anestil|Novocain|2-(diethylamino)ethyl 4-aminobenzoate hydrochloride|Atoxicocaine|Neotonocaine|Allocaine|Aminocaine|Anadolor|Anesthesol|Bernocaine|Chlorocaine|Ethocaine|Euge

规格或纯度：99%

英文名称：Procaine hydrochloride

生化机理：Procaine hydrochloride is a salt of the compound Procaine. Procaine is a noted sodium channel blocker with a variety of inhibitory effects. In skeletal muscle, Procaine has been reported to inhibit calcium-induced calcium release (CICR). Procaine is also noted to act as a DNA methylation inhibitor and to cause demethylation and reactivation of methylation-silenced genes such as RARβ and GSTP1. WIF-1 is noted to be reactivated in a cancer cell line and to downregulate the Wnt canonical pathway. In studies utilizing a neuroblastoma cell line (SHEP), Procaine is reported to induce neuronal apoptosis in a manner correlated with lipid solubility of the compound. In an adult mouse muscle cell line (HEK293), the presence of procaine is reported to potently inhibit nicotinic acetylcholine receptors. Procaine is available alone and in its salt form as Procaine HCl .Na + channel blocker (IC 50 = 60-200 μM). Local anaesthetic properties in vivo. Crosses the blood-brain barrier. Inhibits DNA methylation.

储存温度：充氩

运输条件：常规运输

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产品介绍：Procaine HCl是一种钠离子通道的，NMDA受体以及乙酰胆碱受体抑制剂， IC50分别为60 μM， 0.296 mM何45.5 μM，也是一种，5-HT3抑制剂，KD为1.7 μM。A sodium channel blocker and DNA methylation inhibitorProcaine is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 μM, 0.296 mM and 45.5 μM, which is also an inhibitor of 5-HT3 with KD of 1.7 μM.A sodium channel blocker and DNA methylation inhibitor

PubChem SID：488179937

IUPAC Name：2-(diethylamino)ethyl 4-aminobenzoate;hydrochloride

INCHI：InChI=1S/C13H20N2O2.ClH/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11;/h5-8H,3-4,9-10,14H2,1-2H3;1H

InChi Key：HCBIBCJNVBAKAB-UHFFFAOYSA-N

Canonical SMILES：CCN(CC)CCOC(=O)C1=CC=C(C=C1)N.Cl

Isomeric SMILES：CCN(CC)CCOC(=O)C1=CC=C(C=C1)N.Cl

WGK Germany：3

RTECS：DG2275000

PubChem CID：5795

UN Number：2811

敏感性：对光和空气敏感

熔点：155-156°C

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowedH317 May cause an allergic skin reaction

预防措施声明：P280,P301+P310

Merck Index：7757

个人防护装备：Eyeshields,Faceshields,Gloves,type P2 (EN 143) respirator cartridges

产品包装