产品名称

英文名称：Istaroxime

同义词

Istaroxime、203737-93-3、PST-2744、Istaroxime [INN]、Istaroxime, (E)-、UNII-W8I9H2TPPL、PST 2744、W8I9H2TPPL、CHEMBL469045、W40687GO3S、3-((2-Aminoethoxy)imino)-5alpha-androstan-6,17-dione、(3E,5S,8R,9S,10R,13S,14S)-3-(2-aminoethoxyimino)-10,13-dimethyl-1,2,4,5,7,8,

产品性质

CAS编号：203737-93-3

分子式：C21H32N2O3

分子量：360.49

PubChem编号：9841834

英文别名：Istaroxime|203737-93-3|PST-2744|Istaroxime [INN]|Istaroxime, (E)-|UNII-W8I9H2TPPL|PST 2744|W8I9H2TPPL|CHEMBL469045|W40687GO3S|3-((2-Aminoethoxy)imino)-5alpha-androstan-6,17-dione|(3E,5S,8R,9S,10R,13S,14S)-3-(2-aminoethoxyimino)-10,13-dimethyl-1,2,4,5,7,8,

英文名称：Istaroxime

生化机理：DescriptionIC50 Value 0.43 ± 0.15 μM (Na+/K+-ATPase activity from dog kidney) [1]Istaroxime is a positive inotropic agent that mediates its action throμgh inhibition of sodium/potassium adenosine triphosphatase (Na+/K+ ATPase). Istaroxime is an investigational drμg originally patented and developed by the italian pharmaceutical company Sigma-Tau. Istaroxime is now under development for treatment of acute decompensated heart failure by CVie Therapeutics.in vitro PST2744 inhibited the Na+/K+-ATPase activity from dog kidney with an IC50 value of 0.43 ± 0.15 μM [1]. The transient inward current (I(TI)) induced by a Ca(2+) transient in the presence of complete Na(+)/K(+) pump blockade was inhibited (-43%) by PST2744 but not by digoxin [2].in vivo Intravenous infusion of 0.2 mg/kg/min PST2744 in anesthetized guinea pigs exerted an immediate and long-lasting inotropic effect (ED(80) of 1.89 +/- 0.37 mg/kg) without causing lethal

储存温度：-20°C储存

运输条件：超低温冰袋运输

IUPAC Name：(3E,5S,8R,9S,10R,13S,14S)-3-(2-aminoethoxyimino)-10,13-dimethyl-1,2,4,5,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-6,17-dione

INCHI：InChI=1S/C21H32N2O3/c1-20-7-5-13(23-26-10-9-22)11-17(20)18(24)12-14-15-3-4-19(25)21(15,2)8-6-16(14)20/h14-17H,3-12,22H2,1-2H3/b23-13+/t14-,15-,16-,17+,20+,21-/m0/s1

InChi Key：MPYLDWFDPHRTEG-PAAYLBSLSA-N

Canonical SMILES：CC12CCC(=NOCCN)CC1C(=O)CC3C2CCC4(C3CCC4=O)C

Isomeric SMILES：C[C@]12CC/C(=N\OCCN)/C[C@@H]1C(=O)C[C@@H]3[C@@H]2CC[C@]4([C@H]3CCC4=O)C

PubChem CID：9841834

溶解性：25°C 10 mM in distilled water

产品包装