产品名称

英文名称：Hydroxytacrine maleate salt

同义词

Velnacrine maleate、118909-22-1、9-Amino-1,2,3,4-tetrahydroacridin-1-ol maleate、HYDROXYTACRINE MALEATE、Mentane、HP-029、Velnacrine maleate [USAN]、112964-99-5、HP 029、YY1JW04JCB、Velnacrine maleate, (+)-、Velnacrine maleate, (-)-、WR9885GALS、P83 6029A、DTXSID704515

产品性质

CAS编号：118909-22-1

分子式：C17H18N2O5

分子量：330.34

MDL号：MFCD00069287

PubChem编号：5702293

英文别名：Velnacrine maleate|118909-22-1|9-Amino-1,2,3,4-tetrahydroacridin-1-ol maleate|HYDROXYTACRINE MALEATE|Mentane|HP-029|Velnacrine maleate [USAN]|112964-99-5|HP 029|YY1JW04JCB|Velnacrine maleate, (+)-|Velnacrine maleate, (-)-|WR9885GALS|P83 6029A|DTXSID704515

规格或纯度：98%

英文名称：Hydroxytacrine maleate salt

生化机理：Hydroxytacrine maleate is a cholinesterase inhibitor and a potential Alzheimer’s therapeutic of low toxicity. Exhibits biochemical and pharmacological profile similar to tacrine (THA) except that it is far less toxic and without measurable liver toxicity in humans. Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor (anticholinesterase). It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease, and was marketed under the trade name Cognex. Major form of metabolism is in the liver via hydroxylation of benzylic carbon by CYP450. This forms the major metabolite 1-hydroxy-tacrine (velnacrine) which is still active. Hydroxytacrine maleate is an inhibitor of AChE.

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

产品介绍：A cholinesterase inhibitor that exhibits a biochemical profile very similar to tacrineA cholinesterase inhibitor that exhibits a biochemical profile very similar to tacrine

IUPAC Name：9-amino-1,2,3,4-tetrahydroacridin-1-ol;(Z)-but-2-enedioic acid

INCHI：InChI=1S/C13H14N2O.C4H4O4/c14-13-8-4-1-2-5-9(8)15-10-6-3-7-11(16)12(10)13;5-3(6)1-2-4(7)8/h1-2,4-5,11,16H,3,6-7H2,(H2,14,15);1-2H,(H,5,6)(H,7,8)/b;2-1-

InChi Key：NEEKVKZFYBQFGT-BTJKTKAUSA-N

Canonical SMILES：C1CC(C2=C(C3=CC=CC=C3N=C2C1)N)O.C(=CC(=O)O)C(=O)O

Isomeric SMILES：C1CC(C2=C(C3=CC=CC=C3N=C2C1)N)O.C(=C\C(=O)O)\C(=O)O

PubChem CID：5702293

溶解性：Soluble in water (5 mg/mL warm), DMSO (25 mg/mL), and ethanol (10 mg/mL).

产品包装