产品名称

英文名称：NKP608

同义词

NKP608、177707-12-9、NKP-608、AV-608、nk 608、N-[(2R,4S)-1-[3,5-BIS(TRIFLUOROMETHYL)BENZOYL]-2-[(4-CHLOROPHENYL)METHYL]PIPERIDIN-4-YL]QUINOLINE-4-CARBOXAMIDE、CGP-608、NKP 608、987K1SBI71、4-Quinolinecarboxamide, N-[(2R,4S)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-[(

产品性质

CAS编号：177707-12-9

分子式：C31H24ClF6N3O2

分子量：619.98

PubChem编号：9917079

英文别名：NKP608|177707-12-9|NKP-608|AV-608|nk 608|N-[(2R,4S)-1-[3,5-BIS(TRIFLUOROMETHYL)BENZOYL]-2-[(4-CHLOROPHENYL)METHYL]PIPERIDIN-4-YL]QUINOLINE-4-CARBOXAMIDE|CGP-608|NKP 608|987K1SBI71|4-Quinolinecarboxamide, N-[(2R,4S)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-[(

规格或纯度：≥99%

英文名称：NKP608

生化机理：NKP608 is a non-peptidic derivative of 4-aminopiperidine which acts as a selective, specific and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro and in vivo. In vitro, the binding of NKP608 to bovine retina was characterized by an IC50 of 2.6+/-0.4 nM, whereas the compound's affinity to other receptor binding sites, including NK-2 and NK-3, was much lower. Species differences in IC(50) values with NKP608 were less pronounced than with previously described NK-1 receptor antagonists, being 13+/-2 and 27+/-2 nM in gerbil midbrain and rat striatum, respectively. In vivo, using the hind foot thumping model in gerbils, NKP608 exhibited a potent NK-1 antagonistic activity following oral administration (ID(50)=0.23 mg/kg; 2 h pretreatment), supporting a central activity of NKP608. NKP608 may prove a useful anxiolytic compound.

储存温度：-20°C储存

运输条件：超低温冰袋运输

IUPAC Name：N-[(2R,4S)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-[(4-chlorophenyl)methyl]piperidin-4-yl]quinoline-4-carboxamide

INCHI：InChI=1S/C31H24ClF6N3O2/c32-22-7-5-18(6-8-22)13-24-17-23(40-28(42)26-9-11-39-27-4-2-1-3-25(26)27)10-12-41(24)29(43)19-14-20(30(33,34)35)16-21(15-19)31(36,37)38/h1-9,11,14-16,23-24H,10,12-13,17H2,(H,40,42)/t23-,24+/m0/s1

InChi Key：NXLUTEDAEFXMQR-BJKOFHAPSA-N

Canonical SMILES：C1CN(C(CC1NC(=O)C2=CC=NC3=CC=CC=C23)CC4=CC=C(C=C4)Cl)C(=O)C5=CC(=CC(=C5)C(F)(F)F)C(F)(F)F

Isomeric SMILES：C1CN([C@@H](C[C@H]1NC(=O)C2=CC=NC3=CC=CC=C23)CC4=CC=C(C=C4)Cl)C(=O)C5=CC(=CC(=C5)C(F)(F)F)C(F)(F)F

PubChem CID：9917079

溶解性：DMSO

产品包装