产品名称

英文名称：GAP-134

同义词

DANEGAPTIDE、GAP-134、943134-39-2、(2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid、ZP1609、PA0Y7735AT、943134-39-2 (free base)、ZP-1609、glycyl-(4R)-4-(benzoylamino)-L-proline、L-Proline, glycyl-4-(benzoylamino)-, (4R)-、(2S,4R)-4-benzamido-1-gl

产品性质

CAS编号：943134-39-2

分子式：C14H17N3O4

分子量：291.3

PubChem编号：16656685

英文别名：DANEGAPTIDE|GAP-134|943134-39-2|(2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid|ZP1609|PA0Y7735AT|943134-39-2 (free base)|ZP-1609|glycyl-(4R)-4-(benzoylamino)-L-proline|L-Proline, glycyl-4-(benzoylamino)-, (4R)-|(2S,4R)-4-benzamido-1-gl

英文名称：GAP-134

生化机理：Gap junction uncoupling can alter conduction pathways and promote cardiac re-entry mechanisms that potentiate many supraventricular arrhythmias, such as atrial fibrillation (AF) and atrial flutter (AFL). GAP-134 (Danegaptide), a small modified dipeptide, has been identified as a potent and selective second generation gap junction modifier with oral bioavailability. Gap junction modifier GAP-134, showed consistent efficacy on measures of conduction and AF/AFL inducibility in the canine sterile pericarditis model. GAP-134 is a pharmalogical agent with a favorable clinical safety profile and potential antiarrhythmic efficacy, as already confirmed in phase I clinical trials.

储存温度：-20°C储存

运输条件：超低温冰袋运输

IUPAC Name：(2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid

INCHI：InChI=1S/C14H17N3O4/c15-7-12(18)17-8-10(6-11(17)14(20)21)16-13(19)9-4-2-1-3-5-9/h1-5,10-11H,6-8,15H2,(H,16,19)(H,20,21)/t10-,11+/m1/s1

InChi Key：BIZKIHUJGMSVFD-MNOVXSKESA-N

Canonical SMILES：C1C(CN(C1C(=O)O)C(=O)CN)NC(=O)C2=CC=CC=C2

Isomeric SMILES：C1[C@H](CN([C@@H]1C(=O)O)C(=O)CN)NC(=O)C2=CC=CC=C2

PubChem CID：16656685

溶解性：DMSO

产品包装