产品名称

英文名称：MK-2894

同义词

MK-2894、1006036-87-8、4-[1-[[2,5-dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]thiophene-3-carbonyl]amino]cyclopropyl]benzoic acid、CID 24952929、CHEMBL597997、4-{1-[(2,5-Dimethyl-4-{[4-(trifluoromethyl)phenyl]methyl}thiophene-3-carbonyl)amino]cyclopropyl}ben

产品性质

CAS编号：1006036-87-8

分子式：C25H22F3NO3S

分子量：473.51

PubChem编号：24952929

英文别名：MK-2894|1006036-87-8|4-[1-[[2,5-dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]thiophene-3-carbonyl]amino]cyclopropyl]benzoic acid|CID 24952929|CHEMBL597997|4-{1-[(2,5-Dimethyl-4-{[4-(trifluoromethyl)phenyl]methyl}thiophene-3-carbonyl)amino]cyclopropyl}ben

规格或纯度：≥98%

英文名称：MK-2894

生化机理：MK-2894, a highly potent and selective second generation EP4 antagonist.MK-2894 exhibits favorable pharmacokinetic profile in a number of preclinical species and potent anti-inflammatory activity in several animal models of pain/inflammation. MK-2894 also shows favorable GI tolerability profile in rats when compared to traditional NSAID indomethacin.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：MK-2894 是一种有效的、选择性的、具有高亲和力 (Ki=0.56 nM) 的前列腺素受体 4 (EP4 receptor) 的拮抗剂 (IC50=2.5 nM)。MK-2894 在动物疼痛/炎症模型中具有较强的抗炎活性，可用于关节炎的研究。

IUPAC Name：4-[1-[[2,5-dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]thiophene-3-carbonyl]amino]cyclopropyl]benzoic acid

INCHI：InChI=1S/C25H22F3NO3S/c1-14-20(13-16-3-7-19(8-4-16)25(26,27)28)21(15(2)33-14)22(30)29-24(11-12-24)18-9-5-17(6-10-18)23(31)32/h3-10H,11-13H2,1-2H3,(H,29,30)(H,31,32)

InChi Key：QJZQFVRFJCGDKF-UHFFFAOYSA-N

Canonical SMILES：CC1=C(C(=C(S1)C)C(=O)NC2(CC2)C3=CC=C(C=C3)C(=O)O)CC4=CC=C(C=C4)C(F)(F)F

Isomeric SMILES：CC1=C(C(=C(S1)C)C(=O)NC2(CC2)C3=CC=C(C=C3)C(=O)O)CC4=CC=C(C=C4)C(F)(F)F

PubChem CID：24952929

ChEMBL Ligand：CHEMBL597997

CAS Registry No.：1006036-87-8

GPCRdb Ligand：MK-2894

溶解性：DMSO

产品包装