产品名称

英文名称：Flavopiridol

同义词

L868275、ALVOCIDIB [MART.]、AS-74761、Q4063441、2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidyl]chromen-4-one、4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-((3R,4S)-3-hydroxy-1-methyl-4-piperidinyl)-, rel-(-)-、A25160、Alv、夫拉平度

产品性质

CAS编号：146426-40-6

分子式：C21H20ClNO5

分子量：401.85

PubChem编号：5287969

别名：夫拉平度

英文别名：L868275|ALVOCIDIB [MART.]|AS-74761|Q4063441|2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidyl]chromen-4-one|4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-((3R,4S)-3-hydroxy-1-methyl-4-piperidinyl)-, rel-(-)-|A25160|Alv

规格或纯度：≥99%

英文名称：Flavopiridol

生化机理：Flavopiridol is a synthetic flavone compound that inhibits the phosphorylation of cyclin-dependent kinases (Cdks) and suppresses expression of cyclin D1 and D3, interrupting the central role of Cdks in the regulation of the cell cycle and consequently promoting apoptosis. This action has been exploited in studies investigating the suppression of oncogenic proliferation, synovial hyperplasia, and joint destruction related to rheumatoid arthritis. Flavopiridol is an inhibitor of Cdk1, Cdk10, Cdk11, Cdk2, Cdk3, Cdk4, Cdk5, Cdk6, Cdk7, Cdk8 and Cdk9.

应用：A synthetic flavonoid derivative, potent inhibitor of CDKs.

储存温度：2-8°C储存,充氩

运输条件：冰袋运输

产品介绍：Flavopiridol能与ATP竞争抑制CDK，对CDK1，CDK2，CDK4和CDK6的IC50为40 nM，同时对EGFR和PKA也有一定抑制性。A synthetic flavonoid derivative, potent inhibitor of CDKs.Flavopiridol competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKAA synthetic flavonoid derivative, potent inhibitor of CDKs.

ALogP：3.3

IUPAC Name：2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one

INCHI：InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1

InChi Key：BIIVYFLTOXDAOV-YVEFUNNKSA-N

Canonical SMILES：CN1CCC(C(C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O

Isomeric SMILES：CN1CC[C@@H]([C@@H](C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O

PubChem CID：5287969

CAS Registry No.：146426-40-6

DrugBank Ligand：DB03496

DiscoveRx TREEspot：Flavopiridol|

ChEMBL Ligand：CHEMBL428690

Wikipedia：Alvocidib

RCSB PDB Ligand：CPB

溶解性：DMSO ≥14mg/mL Water <1.2mg/mL Ethanol ≥7.8mg/mL;Soluble in chloroform, and water (slightly soluble).

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

产品包装