产品名称

英文名称：1,2-dioleoyl-sn-glycero-3-phosphate (sodium salt)

同义词

DOPA-NA 、 (Z)-(R)-3-(Phosphonooxy)propane-1,2-diyl dioleate sodium salt 、 L-α-Phosphatidic acid, dioleoyl sodium sal 、 1,2-Di(cis-9-octadecenoyl)-sn-glycerol 3-phosphate sodium salt、1,2-二[顺式-9-十八碳烯酰基]-Sn-甘油-3-磷酸酯钠盐 、 (Z)-(R)-3-(膦酰氧基)丙烷-1,2-二基二油酸酯单钠盐 、 二油酰磷脂酸(钠盐)

产品性质

CAS编号：108392-02-5

分子式：C39H72O8PNa

分子量：722.948

PubChem编号：131865588

别名：1,2-二[顺式-9-十八碳烯酰基]-Sn-甘油-3-磷酸酯钠盐 | (Z)-(R)-3-(膦酰氧基)丙烷-1,2-二基二油酸酯单钠盐 | 二油酰磷脂酸(钠盐)

英文别名：DOPA-NA | (Z)-(R)-3-(Phosphonooxy)propane-1,2-diyl dioleate sodium salt | L-α-Phosphatidic acid, dioleoyl sodium sal | 1,2-Di(cis-9-octadecenoyl)-sn-glycerol 3-phosphate sodium salt

规格或纯度：>99%

英文名称：1,2-dioleoyl-sn-glycero-3-phosphate (sodium salt)

生化机理：磷脂酸(PA)起脂质信使作用。

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：产品介绍181 PA (1,2-二油酰-sn-丙三醇-3-磷酸盐(钠盐))是阴离子脂质。Phosphatidic Acid, Dioleoyl has been shown to activate PKC α, ε, or ζ isotypes in the cytosol of COS cells. This compound not only stimulates PKC-ζ-mediated phosphorylation of distinctive substrates, but additionally causes an upward shift in electrophoretic mobility of PKC &zeta. Furthermore, experiments have reported Phosphatidic Acid to be generated by hydrolysis of phosphatidylcholine, via phospholipase D (PLD). Mechanistic studies suggest activation of PLD by insulin and consequential generation of Phosphatidic Acid which then induces Raf-1 translocation to cell membranes. Raf-1 is an essential component to the mitogen-activated protein kinase cascade, and once it has crossed over to the plasma membrane, other factors may activate it through phosphorylation.An activator of multiple PKC isotypes

INCHI：InChI=1S/C39H73O8P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38(40)45-35-37(36-46-48(42,43)44)47-39(41)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h17-20,37H,3-16,21-36H2,1-2H3,(H2,42,43,44);/b19-17-,20-18-;/t37-;/m1./s1

InChi Key：KHDHADSEKGCPKW-ZBFGHDQJSA-N

Canonical SMILES：CCCCCCCCC=CCCCCCCCC(=O)OCC(COP(=O)(O)O)OC(=O)CCCCCCCC=CCCCCCCCC.[Na]

Isomeric SMILES：CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@H](COP(=O)(O)O)OC(=O)CCCCCCC/C=C\CCCCCCCC.[Na]

WGK Germany：3

关联CAS：116004-31-0

PubChem CID：131865588

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH302 Harmful if swallowed

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P301+P312

个人防护装备：Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

产品包装