产品名称

英文名称：Tamibarotene

同义词

Tamibarotene、94497-51-5、Am 80、4-((5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbamoyl)benzoic acid、AM-80、retinobenzoic acid、Am80、Amnoid、Amnolake、Tamibaro、4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]benzoic acid、TOS-80T、4-[(5,5、他米巴罗汀

产品性质

CAS编号：94497-51-5

分子式：C22H25NO3

分子量：351.44

MDL号：MFCD00866188

PubChem编号：108143

别名：他米巴罗汀

英文别名：Tamibarotene|94497-51-5|Am 80|4-((5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbamoyl)benzoic acid|AM-80|retinobenzoic acid|Am80|Amnoid|Amnolake|Tamibaro|4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]benzoic acid|TOS-80T|4-[(5,5

规格或纯度：≥98%

英文名称：Tamibarotene

生化机理：AM 80 is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. AM 80 displays anticancer activity against acute promyelocytic leukemia in vitro and exhibits antiproliferative effects against a variety of tumor cell lines.Selective retinoic acid receptor α/β (RARα/β) agonist. Induces differentiation and anti-cancer activity in vivo and in vitro .

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Tamibarotene是特异性的RAR-alpha/beta激动剂, 用于治疗全反式视黄酸耐受的急性白血病。A RARα agonist that induces differentiation and apoptosisTamibarotene is a synthetic retinoic acid receptor (RAR) agonist with high specificity for RARα and RARβ over RARγ.A RARα agonist that induces differentiation and apoptosis

ALogP：5.4

IUPAC Name：4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]benzoic acid

INCHI：InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-16(9-10-17(18)21)23-19(24)14-5-7-15(8-6-14)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)

InChi Key：MUTNCGKQJGXKEM-UHFFFAOYSA-N

Canonical SMILES：CC1(CCC(C2=C1C=CC(=C2)NC(=O)C3=CC=C(C=C3)C(=O)O)(C)C)C

Isomeric SMILES：CC1(CCC(C2=C1C=CC(=C2)NC(=O)C3=CC=C(C=C3)C(=O)O)(C)C)C

WGK Germany：3

PubChem CID：108143

DrugBank Ligand：DB04942

CAS Registry No.：94497-51-5

ChEBI：CHEBI32181

ChEMBL Ligand：CHEMBL25202

BindingDB Ligand：50061625

Wikipedia：Tamibarotene

RCSB PDB Ligand：A80

DrugCentral Ligand：3580

溶解性：Soluble in 1.1eq. NaOH (100 mM), DMSO (50 mM), methanol, and water (slightly).

产品包装