产品名称

英文名称：QNZ (EVP4593)

同义词

545380-34-5、QNZ、6-Amino-4-(4-phenoxyphenylethylamino)quinazoline、EVP4593、QNZ (EVP4593)、N4-(4-phenoxyphenethyl)quinazoline-4,6-diamine、4-N-[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine、EVP-4593、NF-kB activation inhibitor、QNZ(EVP4593)、N4-[2-(4-phenoxyph、EVP-4593、N4-(4-苯氧基苯乙基)喹唑啉-4,6-二胺、N4-[2-(4-苯氧基苯基)乙基]-4,6-喹唑啉二胺、6-氨基-4-[2-(4-苯氧基苯基)乙氨基]喹唑啉

产品性质

CAS编号：545380-34-5

分子式：C22H20N4O

分子量：356.42

MDL号：MFCD06411436

PubChem编号：509554

别名：EVP-4593|N4-(4-苯氧基苯乙基)喹唑啉-4,6-二胺|N4-[2-(4-苯氧基苯基)乙基]-4,6-喹唑啉二胺|6-氨基-4-[2-(4-苯氧基苯基)乙氨基]喹唑啉

英文别名：545380-34-5|QNZ|6-Amino-4-(4-phenoxyphenylethylamino)quinazoline|EVP4593|QNZ (EVP4593)|N4-(4-phenoxyphenethyl)quinazoline-4,6-diamine|4-N-[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine|EVP-4593|NF-kB activation inhibitor|QNZ(EVP4593)|N4-[2-(4-phenoxyph

规格或纯度：≥98%

英文名称：QNZ (EVP4593)

生化机理：QNZ inhibits the activation of the transcription factor NF-κB and has been used to investigate NF-κB signaling. Improper activation of NF-κB has been linked to cancer, immune and inflammatory diseases, and viral infection. Research results sμggest that QNZ fully blocks the increase in K currents in rat sensory neurons. QNZ has been used to study colorectal cancer and Schwann cell functioning.Potent, selective NF-kB inhibitor (IC 50 = 11 nM). Inhibits LPS-induced TNFα production (IC 50 = 7 nM). Reduces edema in inflammation in vivo.EVP4593 is a high affinity partial antagonist of NF-KB pathway activation acting by inhibiting store-operated calcium (Ca2+) entry (SOC). It appears that EVP4593 targets heteromeric channels containing TRPC1 as one of the subunits in HD neurons. EVP4593 exhibits neuroprotective effects from glutamate toxicity in nanomolar concentrations.

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：QNZ (EVP4593)有效抑制NF-κB激活和TNF-α产生，IC50分别为11 nM和7 nM。An inhibitor of the transcription factor NFκB.产品介绍QNZ (EVP4593) 强抑制 NF-κB 转录激活和 TNF-α 产生，IC50 分别为 11 和 7 nM。QNZ (EVP4593) 是一种保护神经的钙池操纵的钙通道 (SOC) 抑制剂。QNZ (EVP4593)有效抑制NF-κB激活和TNF-α产生，在Jurkat T细胞中IC50分别为11 nM和7 nM。QNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM, respectively.An inhibitor of the transcription factor NFκB.

IUPAC Name：4-N-[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine

INCHI：InChI=1S/C22H20N4O/c23-17-8-11-21-20(14-17)22(26-15-25-21)24-13-12-16-6-9-19(10-7-16)27-18-4-2-1-3-5-18/h1-11,14-15H,12-13,23H2,(H,24,25,26)

InChi Key：IBAKVEUZKHOWNG-UHFFFAOYSA-N

Canonical SMILES：C1=CC=C(C=C1)OC2=CC=C(C=C2)CCNC3=NC=NC4=C3C=C(C=C4)N

Isomeric SMILES：C1=CC=C(C=C1)OC2=CC=C(C=C2)CCNC3=NC=NC4=C3C=C(C=C4)N

WGK Germany：3

PubChem CID：509554

ChEMBL Ligand：CHEMBL522502

CAS Registry No.：545380-34-5

溶解性：Soluble in DMSO (20 mg/ml), DMF (30 mg/ml), ethanol (10 mg/ml), and 11 solution DMFPBS(pH 7.2) (0.5 mg/ml).

敏感性：对空气敏感，对热敏感

熔点：184 °C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH413 May cause long lasting harmful effects to aquatic lifeH302 Harmful if swallowedH410 Very toxic to aquatic life with long lasting effects

预防措施声明：P305+P351+P338,P273,P280,P302+P352,P321,P501,P264,P270,P362+P364,P391,P330,P264+P265,P301+P317,P337+P317,P332+P317

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