产品名称

英文名称：N3PT

产品性质

CAS编号：13860-66-7

分子式：C13H19Cl2N3OS

分子量：336.28

PubChem编号：66970987

规格或纯度：≥98%

英文名称：N3PT

生化机理：DescriptionIC50 Value 22 nM(Apo-TK) ; 26 nM (EC50, Cellular TK) [1]N3PT is a potent and selective TK inhibitor both in vitro and in vivo.in vitro N3PT inhibits transketolase activity in a cell based assay. Competitive inhibition of TK by N3PT in cells treated with increasing doses of thiamine, expressed as percentage enzymatic activity (the slope of initial linear range) of controls not treated with compounds [1].in vivo Tumors were induced in mice at day 0 and mice were then treated at day 7 with vehicle alone or with N3PT [2]. Low-thiamine diet enhances the sensitivity to N3PT inhibition of TK in spleen. Animals were switched to diets containing 16.5 mg/kg (unchanged), 5 mg/kg, 1 mg/kg, or 0 mg/kg thiamine, from a normal chow containing 16.5mg/kg thiamine [1].Clinical trial N/A

储存温度：-20°C储存

运输条件：超低温冰袋运输

IUPAC Name：2-[3-[(2-amino-6-methylpyridin-3-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol;chloride;hydrochloride

INCHI：InChI=1S/C13H18N3OS.2ClH/c1-9-3-4-11(13(14)15-9)7-16-8-18-12(5-6-17)10(16)2;;/h3-4,8,17H,5-7H2,1-2H3,(H2,14,15);2*1H/q+1;;/p-1

InChi Key：ZLGKCAQWOASSTP-UHFFFAOYSA-M

Canonical SMILES：CC1=NC(=C(C=C1)C[N+]2=CSC(=C2C)CCO)N.Cl.[Cl-]

Isomeric SMILES：CC1=NC(=C(C=C1)C[N+]2=CSC(=C2C)CCO)N.Cl.[Cl-]

PubChem CID：66970987

溶解性：25°C DMSO

产品包装